glycine hydroxymethyltransferase | 9029-83-8

• 分子结构分类: 转移酶 - 转移一碳基团 - 羟甲基、甲酰基和相关转移酶
• 英文名称: glycine hydroxymethyltransferase
• 英文别名: serine aldolase；threonine aldolase；serine hydroxymethylase；serine hydroxymethyltransferase；allothreonine aldolase；L-serine hydroxymethyltransferase；L-threonine aldolase；serine transhydroxymethylase
• CAS: 9029-83-8

反应信息

• 作为试剂：
  描述：

  琥珀半醛 、 聚甘氨酸 在 sodium hydroxide glycine hydroxymethyltransferase 、 磷酸吡哆醛 、 1,4-二巯基-2,3-丁二醇 作用下， 以 水 为溶剂， 反应 48.0h， 生成 2-(S)-amino-3-(R)-hydroxy-6-carboxyhexanoic acid 、 2-(S)-amino-3-(S)-hydroxy-6-carboxyhexanoic acid
  参考文献：
  名称：

  Enzymatic synthesis of ω-carboxy-β-hydroxy-(l)-α-amino acids

  摘要：

  Commercially available omega-carboxy-aldehydes and glycine have been subjected to the catalytic action of an L-threonine aldolase from Escherichia coli to give the corresponding beta-hydroxy-alpha-(L)-amino acids as a mixture of erythro/threo epimers.Specifically, the reaction with glyoxylic acid (2) gave the epimeric beta-hydroxy-(L)-aspartates (t,e)-9 that could be isolated by ion-exchange chromatography in 67% yield. Following esterification and N-Boc protection, the two epimers could be isolated as pure compounds.Similarly, the aldolase-catalyzed addition of glycine to succinic semialdehyde (4) gave the expected mixture of beta-hydroxy-L-alpha-aminoadipic acids (t)-12 and (e)-12 in 34% yield. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.03.070