1-(2-phenyl-ortho-carboran-1-yl)phenylacetic acid | 145826-14-8

• 英文名称: 1-(2-phenyl-ortho-carboran-1-yl)phenylacetic acid
• CAS: 145826-14-8
• 化学式: C₁₆H₂₂B₁₀O₂
• 分子量: 354.459
• InChiKey: YXJQQUTXFGHMEB-CYBMUJFWSA-N

物化性质

• 熔点：
  224-225 °C

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  甲醇 、 1-(2-phenyl-ortho-carboran-1-yl)phenylacetic acid 在 硫酸 作用下， 以 甲醇 为溶剂， 以85%的产率得到methyl (2-phenyl-o-carboranyl-1)phenylacetate
  参考文献：
  名称：

  摘要：

  The asymmetric synthesis of methyl 2-phenyl-2-(2-phenyl-ortho-carboran-1-yl)pent-4-enoate was carried out by palladium-catalyzed allylation in the presence of amino phosphites of the type (RO)(2)P-O-CH2-CHR'-NR"(2) as chiral ligands.

  DOI：

  10.1023/a:1015572605520
• 作为产物：
  描述：

  1-phenyl-2-benzyllithium-o-carborane 、 二氧化碳 以86%的产率得到1-(2-phenyl-ortho-carboran-1-yl)phenylacetic acid
  参考文献：
  名称：

  Metallization of 1-substituted 1-benzyl-o-carboranes with n-butyllithium and some conversions of 1-R-2-benzyllithium-o-carboranes

  摘要：

  It was shown that 1-R-2-benzyl-o-carboranes (R = Me, i-Pr, Ph, PhCH2) and other derivatives of o-carborane containing an ArCH2 group in positions 1 and 2 are readily metallized by n-butyllithium, forming the corresponding benzyllithium derivatives, which react with electrophilic reagents like the usual organolithium compounds, permitting the synthesis of various C-substituted 1-o-carboranes.

  DOI：

  10.1007/bf00869528