10-(4-azidomethylphenyl)-5,15-dimesitylcorrolegallium(III)(pyridine) | 1586046-68-5

• 英文名称: 10-(4-azidomethylphenyl)-5,15-dimesitylcorrolegallium(III)(pyridine)
• CAS: 1586046-68-5
• 化学式: C₄₉H₄₁GaN₈
• 分子量: 811.641
• InChiKey: YDGYGHCSDRENOD-IEJDEDJDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  8-(4-(N-(prop-2-yn-1-yl)benzamide))-2,8-diethyl-1,3,7,9-tetramethyl-BODIPY 、 10-(4-azidomethylphenyl)-5,15-dimesitylcorrolegallium(III)(pyridine) 在 copper(l) iodide 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以96%的产率得到
  参考文献：
  名称：

  Slow and Fast Singlet Energy Transfers in BODIPY-gallium(III)corrole Dyads Linked by Flexible Chains

  摘要：

  Red (no styryl), green (monostyryl), and blue (distyryl) BODIPY-gallium(III) (BODIPY = boron-dipyrromethene) corrole dyads have been prepared in high yields using click chemistry, and their photophysical properties are reported. An original and efficient control of the direction of the singlet energy transfers is reported, going either from BODIPY to the gallium-corrole units or from gallium-corroles to BODIPY, depending upon the nature of the substitution on BODIPY. In one case (green), both directions are possible. The mechanism for the energy transfers is interpreted by means of through-space Forster resonance energy transfer (FRET).

  DOI：

  10.1021/ic402798f
• 作为产物：
  描述：

  4-(azidomethyl)benzaldehyde 、 2-(二吡咯-2-基)甲基三甲苯 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 10-(4-azidomethylphenyl)-5,15-dimesitylcorrolegallium(III)(pyridine)
  参考文献：
  名称：

  Slow and Fast Singlet Energy Transfers in BODIPY-gallium(III)corrole Dyads Linked by Flexible Chains

  摘要：

  Red (no styryl), green (monostyryl), and blue (distyryl) BODIPY-gallium(III) (BODIPY = boron-dipyrromethene) corrole dyads have been prepared in high yields using click chemistry, and their photophysical properties are reported. An original and efficient control of the direction of the singlet energy transfers is reported, going either from BODIPY to the gallium-corrole units or from gallium-corroles to BODIPY, depending upon the nature of the substitution on BODIPY. In one case (green), both directions are possible. The mechanism for the energy transfers is interpreted by means of through-space Forster resonance energy transfer (FRET).

  DOI：

  10.1021/ic402798f

文献信息

• Easy access to heterobimetallic complexes for medical imaging applications via microwave-enhanced cycloaddition
  作者：Nicolas Desbois、Sandrine Pacquelet、Adrien Dubois、Clément Michelin、Claude P Gros

  DOI：10.3762/bjoc.11.239

  日期：——

  The Cu(I)-catalysed Huisgen cycloaddition, known as “click” reaction, has been applied to the synthesis of a range of triazole-linked porphyrin/corrole to DOTA/NOTA derivatives. Microwave irradiation significantly accelerates the reaction. The synthesis of heterobimetallic complexes was easily achieved in up to 60% isolated yield. Heterobimetallic complexes were easily prepared as potential MRI/PET (SPECT) bimodal contrast agents incorporating one metal (Mn, Gd) for the enhancement of contrast for MRI applications and one “cold” metal (Cu, Ga, In) for future radionuclear imaging applications. Preliminary relaxivity measurements showed that the reported complexes are promising contrast agents (CA) in MRI.

  Cu(I)催化的Huisgen环加成反应，也称为“点击”反应，已应用于合成一系列三唑连接的卟啉/卡烯类到DOTA/NOTA衍生物。微波辐射显著加速了反应。异质双金属配合物的合成可轻易地达到高达60%的分离收率。异质双金属配合物可作为潜在的MRI/PET（SPECT）双模式对比剂，包含一种金属（Mn，Gd）用于增强MRI应用的对比度，以及一种“冷”金属（Cu，Ga，In）用于未来的放射核成像应用。初步的弛豫度测量显示所报道的配合物是MRI中有前途的对比剂（CA）。