N-(tert-butyl)-2-(4-fluorophenyl)-2-oxoethanesulfonamide | 1334654-99-7

• 英文名称: N-(tert-butyl)-2-(4-fluorophenyl)-2-oxoethanesulfonamide
• 英文别名: N-tert-butyl-2-(4-fluorophenyl)-2-oxoethanesulfonamide
• CAS: 1334654-99-7
• 化学式: C₁₂H₁₆FNO₃S
• 分子量: 273.328
• InChiKey: BLOMBBULCAXQBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(tert-butyl)-2-(4-fluorophenyl)-2-oxoethanesulfonamide 在 ammonium acetate 、 sodium cyanoborohydride 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 22.0h， 生成 2-(4-fluorophenyl)-2-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]oxathiazin-2-ylamino)ethanesulfonamide
  参考文献：
  名称：

  DI AND TRI - SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF

  摘要：

  该发明涉及公式（I）的化合物及其生理兼容盐。这些化合物适用于治疗高血糖，例如。

  公开号：

  US20130338150A1
• 作为产物：
  描述：

  对氟苯甲酸甲酯 、 N-(叔丁基)-甲磺酰胺 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.08h， 以662 mg的产率得到N-(tert-butyl)-2-(4-fluorophenyl)-2-oxoethanesulfonamide
  参考文献：
  名称：

  DI- AND TRI-SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF

  摘要：

  该发明涉及式(I)的化合物及其生理兼容盐。所述化合物适用于治疗高血糖，例如。

  公开号：

  US20130345125A1

文献信息

• TETRASUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF
  申请人：Boehme Thomas

  公开号：US20140024584A1

  公开（公告）日：2014-01-23

  The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.

  该发明涉及式(I)的化合物以及其生理上可接受的盐。所述化合物适用于治疗高血糖等情况。
• BRANCHED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Boehme Thomas

  公开号：US20130345126A1

  公开（公告）日：2013-12-26

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  该发明涉及公式(I)的化合物及其生理相容盐。所述化合物适用于治疗高血糖，例如。
• Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
  申请人：Boehme Thomas

  公开号：US08871758B2

  公开（公告）日：2014-10-28

  The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.

  本发明涉及式(I)的化合物及其生理上可接受的盐。所述化合物适用于例如治疗高血糖等方面。
• Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
  申请人：Boehme Thomas

  公开号：US08710050B2

  公开（公告）日：2014-04-29

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  本发明涉及式(I)化合物及其生理相容盐。该化合物适用于治疗高血糖等疾病。
• Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
  申请人：Boehme Thomas

  公开号：US08828994B2

  公开（公告）日：2014-09-09

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  本发明涉及公式(I)的化合物及其生理相容盐。该化合物适用于治疗高血糖等疾病。