cobalt meso-tetrakis[4-(N-trimethyl)aminophenyl]porphophine | 80137-20-8

• 英文名称: cobalt meso-tetrakis[4-(N-trimethyl)aminophenyl]porphophine
• 英文别名: (tetrakis(N,N,N-trimethyl-4-anilino)porphyrin)cobalt(II)；[Co(II)(meso-tetrakis(N,N,N-trimethylaniliniumyl)porphyrin]；Mn(meso-tetrakis[4-(N-trimethyl)aminophenyl]porphophine)
• CAS: 80137-20-8
• 化学式: C₅₆H₆₀CoN₈
• 分子量: 904.139
• InChiKey: PJTFRPAZAZVPJG-YUTFXDKVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  cobalt meso-tetrakis[4-(N-trimethyl)aminophenyl]porphophine 以 盐酸 为溶剂， 生成 钴
  参考文献：
  名称：

  Iron(II) and magnesium(II) porphyrin acid solvolysis reactions

  摘要：

  DOI：

  10.1016/0020-1650(81)80004-9
• 作为产物：
  描述：

  meso-tetrakis(N,N,N-trimethylanilinium-4-yl)porphine Co(I) complex 在 水 作用下， 以 乙腈 为溶剂， 生成 cobalt meso-tetrakis[4-(N-trimethyl)aminophenyl]porphophine
  参考文献：
  名称：

  Kellett, Richard M.; Spiro, Thomas G., Inorganic Chemistry, 1985, vol. 24, # 15, p. 2373 - 2377

  摘要：

  DOI：
• 作为试剂：
  描述：

  水 在 cobalt meso-tetrakis[4-(N-trimethyl)aminophenyl]porphophine 作用下， 以 水 为溶剂， 以>90的产率得到氢气
  参考文献：
  名称：

  Kellett, Richard M.; Spiro, Thomas G., Inorganic Chemistry, 1985, vol. 24, # 15, p. 2373 - 2377

  摘要：

  DOI：

文献信息

• One-electron-transfer reactions of the couple sulfur dioxide/sulfur dioxide radical anion in aqueous solutions. Pulse radiolytic and cyclic voltammetric studies
  作者：P. Neta、Robert E. Huie、Anthony. Harriman

  DOI：10.1021/j100290a063

  日期：1987.3
• Haye, Shirleyanne E.; Hambright, Peter, Inorganic Chemistry, 1984, vol. 23, # 26, p. 4777 - 4779
  作者：Haye, Shirleyanne E.、Hambright, Peter

  DOI：——

  日期：——
• Synthesis and DNA Binding of Novel Water-Soluble Cationic Methylcobalt Porphyrins
  作者：Jenna S. Trommel、Luigi G. Marzilli

  DOI：10.1021/ic010232e

  日期：2001.8.1

  Organocobalt derivatives of tetracationic water-soluble porphyrins are difficult to prepare via the typical reductive alkylation of the Co(II)(por) (porH(2) = porphyrin ligand). None have been reported. The problem may arise because the porphyrin core is made relatively electron poor by the positively charged peripheral groups. We have circumvented this problem by using the [Co(III)(NH(3))(5)CH(3)](2+) reagent, which inserts the Co(III)-CH(3) moiety directly into porH(2) in water under basic conditions. The method afforded two new [CH(3)Co(por)](4+) derivatives, [CH(3)CoTMpyP(4)](4+) and [CH(3)CoTMAP](4+), where [TMpyP(4)](4+) and [TMAP](4+) are the coordinated, NH-deprotonated forms of meso-tetrakis(N-methyl-4-pyridiniumyl)porphyrin and meso-tetrakis(N,N,N-trimethylaniliniumyl)porphyrin, respectively. The binding of the two new [CH(3)Co(por)](4+) cations to DNA and to the synthetic DNA polymers [poly(dA-dT)](2) and [poly(dG-dC)](2) was studied. Using published criteria by which changes in DNA viscosity and in the visible and CD spectra in the Soret region can be used to assess DNA binding, we conclude that both are outside binders. A large hypochromicity of the Soret bands of the [CH(3)Co(por)](4+) cations observed upon outside binding to DNA may indicate a high degree of self-stacking. The visible absorption and CD spectra of the [CH(3)Co(por)](4+) cations in the presence of 1:1 mixtures of [poly(dA-dT)](2) and [poly(dG-dC)](2) are nearly identical to those with [poly(dA-dT)](2) alone and are very different from those of [poly(dG-dC)](2) alone. Thus, both cations show a high preference for outside binding at AT-rich over GC-rich DNA sites. Upon binding of each of the [CH(3)Co(por)](4+) cations to all of the DNA polymers, the Soret bands exhibit blue shifts, whereas the Soret bands of the corresponding [(H(2)O)(2)Co(por)](5+) cations exhibit red shifts. The blue shifts strongly suggest that the [CH(3)Co(por)](4+) cations, particularly [CH(3)CoTMAP](4+), become five-coordinate forms to some extent on DNA binding; this result is the first good evidence for the presence at equilibrium of five-coordinate CH(3)Co(III)(N(4)) forms in water.