1,1'-bis[3-(2-trimethylsilyletoxy)propyl]ferrocene | 949107-86-2

• 英文名称: 1,1'-bis[3-(2-trimethylsilyletoxy)propyl]ferrocene
• CAS: 949107-86-2
• 化学式: C₂₆H₄₆FeO₂Si₂
• 分子量: 502.668
• InChiKey: NIJXVPBLFASTAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  1,1'-bis[3-(2-trimethylsilyletoxy)propyl]ferrocene 、 水 在 盐酸 、 lithium tetrafluoroborate 、 锌 作用下， 以 正己烷 、 乙腈 为溶剂， 以72%的产率得到1,1'-di(3-hydroxypropyl)ferrocene
  参考文献：
  名称：

  1,1′-Bis(3-hydroxypropyl)ferrocene: Preparation and substitution with polyfluoroalkyl groups

  摘要：

  SiMe3CH2CH2 was demonstrated as a robust and convenient OH protecting group in the preparation of 1,1'-bis(3-hydroxypropyl)ferrocene (1). The OH groups were used to introduce polyfluorinated alkyl chains by acylation of 1 with (C2F5CO)20 and alkylation with CF3(CF2)(6)CH2OH under Mitsunobu reaction conditions. This demonstrates a new method for introduction of an omega-hydroxyalkyl group to the Cp unit as a synthetic handle for modification of molecular properties. (c) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2007.05.005
• 作为产物：
  描述：

  3-(2-trimethylsilyletoxy)propylcyclopentadiene 、 iron(II) chloride 在 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 以84%的产率得到1,1'-bis[3-(2-trimethylsilyletoxy)propyl]ferrocene
  参考文献：
  名称：

  1,1′-Bis(3-hydroxypropyl)ferrocene: Preparation and substitution with polyfluoroalkyl groups

  摘要：

  SiMe3CH2CH2 was demonstrated as a robust and convenient OH protecting group in the preparation of 1,1'-bis(3-hydroxypropyl)ferrocene (1). The OH groups were used to introduce polyfluorinated alkyl chains by acylation of 1 with (C2F5CO)20 and alkylation with CF3(CF2)(6)CH2OH under Mitsunobu reaction conditions. This demonstrates a new method for introduction of an omega-hydroxyalkyl group to the Cp unit as a synthetic handle for modification of molecular properties. (c) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2007.05.005