1-NH2CH2-1,2-closo-C2B10H11 | 23836-16-0

• 英文名称: 1-NH2CH2-1,2-closo-C2B10H11
• 英文别名: 1-(aminomethyl)-1,2-closo-dicarbadodecaborane(12)；1-aminomethyl-1,2-dicarba-closo-dodecaborane(12)；o-closo-carboranylmethylamine；1-aminomethyl-1,2-carborane；1-NH₂CH₂-1,2-closo-C₂B₁₀H₁₁
• CAS: 23836-16-0
• 化学式: C₃H₁₅B₁₀N
• 分子量: 173.269
• InChiKey: MTRDBNVDGNXXME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1-NH2CH2-1,2-closo-C2B10H11 在 磺酰胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以80%的产率得到1-methylenesulfamide-1,2-dicarba-closo-dodecaborane
  参考文献：
  名称：

  [EN] CARBONIC ANHYDRASE INHIBITORS AND METHOD OF THEIR PRODUCTION
  [FR] INHIBITEURS DE L'ANHYDRASE CARBONIQUE ET PROCÉDÉ DE PRODUCTION ASSOCIÉ

  摘要：

  该发明描述了一般式（I）的硼簇化合物的新衍生物及其药学上可接受的盐和溶剂，以及它们对酶碳酸酐酶IX的特异抑制作用，该酶在癌组织中过度表达。该发明还包括合成方法和新型衍生物的用途。该发明的人类碳酸酐酶IX的抑制剂可以作为用于癌症疾病诊断和/或治疗的药物的活性化合物。（式（I））

  公开号：

  WO2013060307A1
• 作为产物：
  描述：

  1-(aminomethyl)-1,2-closo-dodecaborane hydrochloride 以 solid 为溶剂， 生成 1-NH2CH2-1,2-closo-C2B10H11
  参考文献：
  名称：

  Malmquist, Jonas; Sjöberg, Stefan, Inorganic Chemistry, 1992, vol. 31, # 12, p. 2534 - 2537

  摘要：

  DOI：

文献信息

• The first examples of platinum(II)-amine complexes containing 1,2-dicarba-closo-dodecaborane(12)
  作者：Jean A. Todd、Louis M. Rendina

  DOI：10.1016/j.inoche.2003.11.027

  日期：2004.2

  Treatment of the labile precursor complexes cis- or trans-[PtCl(dmf)(NH3)2]OTf (dmf=N,N-dimethylformamide; OTf=trifluoromethanesulfonate) with the monodentate 1-aminoalkyl-1,2-carborane ligands NH2(CH2)nC2B10H11 (n=1,3) afforded the moderately-stable species cis- or trans-[PtCl(NH3)2NH2(CH2)nC2B10H11}]OTf, respectively. The novel complexes are the first examples of platinum(II)-amine derivatives containing

  摘要 用单齿 1-氨基烷基-1,2-碳硼烷配体 NH2 处理不稳定的前体配合物顺式或反式 [PtCl(dmf)(NH3)2]OTf（dmf=N,N-二甲基甲酰胺；OTf=三氟甲磺酸盐） (CH2)nC2B10H11 (n=1,3) 分别提供了中等稳定的顺式或反式 [PtCl(NH3)2NH2( )nC2B10H11}]OTf。新型配合物是铂 (II)-胺衍生物的第一个例子，其中包含 1,2-二碳- closo-ddecaborane(12) (closo-1,2-carborane) 配体。
• CARBONIC ANHYDRASE INHIBITORS AND METHOD OF THEIR PRODUCTION
  申请人：USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY, v.v.i.

  公开号：US20140303390A1

  公开（公告）日：2014-10-09

  Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.

  一般式为I的硼团簇化合物及其药学上可接受的盐和溶剂的衍生物，以及它们对酶碳酸酐酶IX的特定抑制作用。合成方法和新衍生物的用途。这些人类碳酸酐酶IX的抑制剂可以用作诊断和/或治疗癌症疾病的药物的活性化合物。
• The role of polycyclic frameworks in modulating P2X7 receptor function
  作者：Timothy B. Callis、Tristan A. Reekie、James O'Brien-Brown、Erick C.N. Wong、Eryn L. Werry、Nabiha Elias、William T. Jorgensen、John Tsanaktsidis、Louis M. Rendina、Michael Kassiou

  DOI：10.1016/j.tet.2017.10.075

  日期：2018.3

  Herein we describe our recent attempts to target the P2X7 receptor for potential treatment of neurological disorders. This work focusses on different polycycles including carborane, adamantane or cubane, joined by either a cyanoguanidine or an amide linker to phenyl or isoquinoline moieties. We have demonstrated the superiority of the adamantyl moiety over other polycycles in terms of synthetic accessibility and biological (cellular) activity. We have also shown that an amide or cyanoguanidine linker can greatly alter the biological activity of compounds. This SAR study provides important insights into the types of functionality required to target the P2X7 receptor. (C) 2017 Elsevier Ltd. All rights reserved.
• Coupling of Amino Carboranes to Carboxylic Acid Containing Substrates
  作者：Ye Wu、William Quintana

  DOI：10.1021/ic981223h

  日期：1999.5.1

  The reactivity of the known amino carboranes 1-H2NCH2-1,2-C2B10H11 and 7-H3N-7-CB10H12 With carboxylic acid containing substrates was investigated. The reactions studied using the coupling reagent, 1,1'-carbonyldiimidazole, resulted in the preparation of a series of amides in moderate to high yield. The relative importance of this type of research resides in the fact that it allows the introduction of amino acids in close contact with the carborane cage. These compounds can constitute a new generation of substrates useful in boron neutron capture therapy. Our emphasis lies in the development of suitable synthetic schemes allowing the preparation of this type of compound. Experimental details and analytical data supporting the formulation of the prepared compounds are reported.