[CuZn(1,3-bis(salicylidenamino)propane)Cl₂] | 21044-50-8

• 英文名称: [CuZn(1,3-bis(salicylidenamino)propane)Cl₂]
• 英文别名: [CuZn(salpn)Cl₂]；dichloro-2κ(2)Cl-μ-(2,2'-[1,3-propanediylbis(nitrilomethylidyne)]diphenolato)-1κ(4)O,N,N',O';2.kappa(2)O,O'-copper(II)zinc(II)；([μ-bis(salicylidene)-1,3-propanediaminato]copper(II))dichlorozinc(II)；[CuZnCl2(N,N'-bis(salicylidene)-1,3-propanediamine-2H)]
• CAS: 21044-50-8
• 化学式: C₁₇H₁₆Cl₂CuN₂O₂Zn
• 分子量: 480.168
• InChiKey: BUGZCGSOFFMCSU-DQIPMIPLSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  N,N'-二亚水杨基-1,3-二氨基丙烷 在 NH₃ 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 生成 [CuZn(1,3-bis(salicylidenamino)propane)Cl₂]
  参考文献：
  名称：

  {[μ-Bis(salicylidene)-1,3-propanediaminato]-copper(II)}dichlorozinc(II)

  摘要：

  The title compound, [CUZnCl2(C17H16N2O2)], is a double oxygen-bridged hetero-dinuclear complex. The Cu2+ atom has a distorted square-planar environment involving the two O and two N atoms from the bis(salicylidene)-1,3-propanediaminate (SALPD(2-)) ligand. The average Cu-O distance is 1.940(3) Angstrom and the average Cu-N distance is 1.966(3) Angstrom. The coordination around the Zn2+ atom is distorted tetrahedral, with average Zn-O and Zn-Cl distances of 2.007(3) and 2.208(1) Angstrom, respectively. In the bridging plane, the Zn-Ol-Cu, Zn-O2-Cu, O1-Zn-O2 and O1-Cu-O2 angles are 102.4(1), 102.3(1), 75.0(1) and 78,1(1)degrees, respectively.

  DOI：

  10.1107/s0108270199003091

文献信息

• Synthesis, characterization and activity of imidazolate-bridged and Schiff-base dinuclear complexes as models of Cu,Zn-SOD. A comparative study
  作者：Verónica A. Daier、Eric Rivière、Sonia Mallet-Ladeira、Diego M. Moreno、Christelle Hureau、Sandra R. Signorella

  DOI：10.1016/j.jinorgbio.2016.07.008

  日期：2016.10

  [CuZn(dien)2(mu-Im)](ClO4)3.MeOH (1) and [Cu2(dien)2(mu-Im)](ClO4)3 (2) (Im = imidazole, dien=diethylenetriamine), and two complexes formed with Schiff base ligands, [CuZn(salpn)Cl2] (3) and [Cu2(salbutO)ClO4] (4) (H2salpn=1,3-bis(salicylidenamino)propane, H3salbutO=1,4-bis(salicylidenamino)butan-2-ol) have been prepared and characterized. The reaction of [Cu(dien)(ImH)](ClO4)2 with [Zn(dien)(H2O)](ClO4)2

  两种咪唑基桥联的diCuII和CuIIZnII配合物[CuZn（dien）2（mu-Im）]（ClO4）3.MeOH（1）和[Cu2（dien）2（mu-Im）]（ ）3（2） （Im =咪唑，二烯=二亚乙基三胺），和两个由席夫碱配体形成的络合物[CuZn（salpn）Cl2]（3）和[Cu2（salbutO） ]（4）（H2salpn = 1,3-bis（salicylidenamino） ）丙烷，已制备并表征了H 3 salbutO ＝ 1，4-双（水杨酰亚胺基氨基）丁烷-2-醇）。[Cu（dien）（ImH）]（ ）2与[Zn（dien）（H2O）]（ ）2在pH> / = 11的反应生成配合物1；在较低pH下，Cu3Zn四核配合物[（dien）Cu（mu-Im）} 3Zn（OH2）（ ）2]（ ）3（1a）形成为主要反应产物。1a的X射线衍射表
• Preparation and structural characterization of hetero-dinuclear Schiff base copper(II)–zinc(II) complexes and their inhibition studies on Helicobacter pylori urease
  作者：Zhong-Lu You、Yao Lu、Na Zhang、Bo-Wen Ding、Hui Sun、Peng Hou、Che Wang

  DOI：10.1016/j.poly.2011.05.048

  日期：2011.8

  A series of hetero-dinuclear Cu-II-Zn-II complexes, [CuZnCl2L1] (1), [CuZnCl2L2] (2), [CuZnBr2L3] (3), [CuZnBr2L4(DMF)] (4), [CuZnCl2L4] (5), [CuZnCl2L5] (6), [CuZnCl2L3] (7) and [CuZnBr2L1] (8), where L-3, L-4 and L-5 are the deprotonated forms of N,N'-bis(3-ethoxysalicylidene)-1,3-propanediamine (H2L1), N,N'-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine (H2L2), N,N'-bis(3-methoxysalicylidene)-1,3-propanediamine (H2L3), N,N'-bis(salicylidene)-1,3-propanediamine (H2L4) and N,N'-bis(salicylidene)1,4-butanediamine (H2L5), respectively, have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. The complexes were tested for their urease inhibitory activity. Complexes 1 and 8 show effective urease inhibitory activity with IC50 values of 2.2 and 10.7 mu M. The molecular docking study of the complexes with the Helicobacter pylori urease was performed. (C) 2011 Elsevier Ltd. All rights reserved.