N-[1-(1-naphthyl)ethyl]-1,4,7,10-tetraazacyclododecane-1-acetamide | 1512804-14-6

• 英文名称: N-[1-(1-naphthyl)ethyl]-1,4,7,10-tetraazacyclododecane-1-acetamide
• 英文别名: N-(1-naphthalen-1-ylethyl)-2-(1,4,7,10-tetrazacyclododec-1-yl)acetamide
• CAS: 1512804-14-6
• 化学式: C₂₂H₃₃N₅O
• 分子量: 383.537
• InChiKey: WVYQREHQWHQFGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  28.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  68.43
• 氢给体数：
  4.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  N-[1-(1-naphthyl)ethyl]-1,4,7,10-tetraazacyclododecane-1-acetamide 、 1,2-bis(12-bromododecyl)disulfane 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 96.0h， 生成
  参考文献：
  名称：

  Lanthanide-Functionalized Nanoparticles as MRI and Luminescent Probes for Sensing and/or Imaging Applications

  摘要：

  The combination of lanthanides and nanoparticles to develop new hybrid nanomaterials has become a highly topical area of research in the field of sensing, biomedical imaging, drug delivery, etc. However, these novel nanomaterials have to be carefully designed to ensure that the unique properties conveyed by each component, i.e., lanthanide ions and nanoparticles, are maximized and not negatively affected by one another. In this Forum Article, the main advances in the design of lanthanide-based nanoparticles will be discussed, with the first part focusing on the design of gadolinium(III)-based nanoparticles and their use as magnetic resonance imaging agents. The second part will then describe the main and most recent designs of luminescent lanthanide-based nanoparticles and their applications as sensors or imaging agents, with a special emphasis on our contribution to this area.

  DOI：

  10.1021/ic4023568
• 作为产物：
  描述：

  轮环藤宁 、 2-chloro-N-(1-naphthylethyl)acetamide 在 三乙胺 作用下， 以 氯仿 为溶剂， 以100%的产率得到N-[1-(1-naphthyl)ethyl]-1,4,7,10-tetraazacyclododecane-1-acetamide
  参考文献：
  名称：

  Lanthanide-Functionalized Nanoparticles as MRI and Luminescent Probes for Sensing and/or Imaging Applications

  摘要：

  The combination of lanthanides and nanoparticles to develop new hybrid nanomaterials has become a highly topical area of research in the field of sensing, biomedical imaging, drug delivery, etc. However, these novel nanomaterials have to be carefully designed to ensure that the unique properties conveyed by each component, i.e., lanthanide ions and nanoparticles, are maximized and not negatively affected by one another. In this Forum Article, the main advances in the design of lanthanide-based nanoparticles will be discussed, with the first part focusing on the design of gadolinium(III)-based nanoparticles and their use as magnetic resonance imaging agents. The second part will then describe the main and most recent designs of luminescent lanthanide-based nanoparticles and their applications as sensors or imaging agents, with a special emphasis on our contribution to this area.

  DOI：

  10.1021/ic4023568