[Ru(N-(2-hydroxyethyl)ethylenediaminetriacetate)(η(2)(1,6)-4-methylpyrimidine-N1)](1-) | 141261-25-8

• 英文名称: [Ru(N-(2-hydroxyethyl)ethylenediaminetriacetate)(η(2)(1,6)-4-methylpyrimidine-N1)](1-)
• 英文别名: [Ru(N-(2-hydroxyethyl)ethylenediaminetriacetate)(η(2)(1,2)-4-methylpyrimidine-N1)](1-)；[Ru(N-(2-hydroxyethyl)ethylenediaminetriacetate)(η(2)(5,6)-4-methylpyrimidine-N1)](1-)；[Ru(N-(2-hydroxyethyl)ethylenediaminetriacetate)(4-methylpyrimidine-N1)](1-)
• CAS: 141261-25-8；155916-79-3；155916-78-2；186038-98-2
• 化学式: C₁₅H₂₁N₄O₇Ru
• 分子量: 470.424
• InChiKey: APUQYXFBMHNRRO-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  4-甲基嘧啶 、 Na[Ru(N-hydroxyethylethylenediamine-N,N',N'-triacetate)(H2O)] 在 重水 、 汞 、 锌 作用下， 以 重水 为溶剂， 生成 [Ru(N-(2-hydroxyethyl)ethylenediaminetriacetate)(η(2)(5,6)-4-methylpyrimidine-N1)](1-) 、 [Ru(N-(2-hydroxyethyl)ethylenediaminetriacetate)(η(2)(5,6)-4-methylpyrimidine-N1)](1-) 、 [Ru(N-(2-hydroxyethyl)ethylenediaminetriacetate)(η(2)(5,6)-4-methylpyrimidine-N1)](1-) 、 [Ru(N-(2-hydroxyethyl)ethylenediaminetriacetate)(η(2)(1,6)-4-methylpyrimidine-N1)](1-)
  参考文献：
  名称：

  N-1- and η²-Pyrimidine Linkage Isomers in Complexes of [Ru^II(hedta)]^-

  摘要：

  [Ru-II(hedta)(H2O)](-), hedta(3-) = N-hydroxyethylethylenediaminetriacetate, forms N-1-bound pyrimidine complexes via a kinetically controlled substitution at N-1 with pyrimidine (pym), 4-methylpyrimidine (4CH(3)pym), and 4,6-dimethylpyrimidine (Me(2)pym); k = 31 M(-1) s(-1) for pym. Subsequent to N-1 coordination, an intramolecular redistribution of Ru-II-pyrimidine linkage isomers occurs with the formation of eta(2) attachments, reaching equilibrium with t(1/2)'s Of 28.8 (pym), 24 (4CH(3)pym), and 1 h for Me(2)pym. The N-1 forms exhibit normal Ru-II/III waves at 0.14 (pym), 0.10 (4CH(3)pym), and 0.16 V (Me(2)pym) whereas the eta(2) forms shift to more positive values indicative of better pi-acceptor attachments: 0.50 (pym) and 0.44 V (4CH(3)pym). The ratio of isomers was determined to be as follows by H-1 NMR and C-13 NMR methods: (pym) eta(2)(1,2):eta(2)(5,6):eta(2)(1,6):N-1 of 43:22:33:2;(4CH(3)pym) eta(2)(1,2):eta(2)(5,6):N-1 of 10:33:57; (Menpym) eta(2)(1,2):eta(2)(5,6):N-1 of 6:26:68. H-1 NMR assignments have been made for all the observed N-1, eta(2)(1,2), eta(2)(5,6), and eta(2)(1,6) isomers. C-13 NMR shifts have been identified for the major isomers of pym and 4CH(3)pym and confirmed HH COSY and HC COSY methods. Several important conclusions are drawn: (1) eta(2) isomers of the eta(2)(1,2) type exhibit significant downfield shifts of H2 of ca 1.20 ppm; (2) C-13 NMR shifts of carbon centers in eta(2)-bound diazine rings are downfield of the free ligand by up to +9 ppm and not 40-80 ppm upfield as for eta(2)-olefinic complexes; (3) eta(2) protons of the eta(2)(5,6) type shift significantly less upfield than those for eta(2)-olefin complexes (ca. 0.4-0.8 ppm vs 1.0-2.0 ppm). It was established that the formation of eta(2)-bound pyrimidines of [Ru-II(hedta)](-) occurs concomitantly with the dissociation of a carboxylate donor of the hedta(3-) ligand, C-13 NMR spectra reveal the predicted weighted percentage of freed carboxylates based on the isomer distribution between N-1 with all three glycinato arms of hedta(3-) bound to Ru-II (C-13 resonance at 188 ppm) vs eta(2) forms with two bound glycinato groups and one free glycinato group of hedta(3-) (resonating near 174 ppm).

  DOI：

  10.1021/ic961048+

文献信息

• Zhang, Songsheng; Holl, Lori A.; Shepherd, Rex E., Inorganic Chemistry, 1990, vol. 29, # 5, p. 1012 - 1022
  作者：Zhang, Songsheng、Holl, Lori A.、Shepherd, Rex E.

  DOI：——

  日期：——