bis(η5-cyclopentadienyl)bis(O-diphenylphosphinoacetato)titanium(IV) | 284685-86-5

• 英文名称: bis(η5-cyclopentadienyl)bis(O-diphenylphosphinoacetato)titanium(IV)
• CAS: 284685-86-5
• 化学式: C₃₈H₃₄O₄P₂Ti
• 分子量: 664.513
• InChiKey: UTGIYVIULGXVDA-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  bis(η5-cyclopentadienyl)bis(O-diphenylphosphinoacetato)titanium(IV) 、 copper(l) chloride 以 二氯甲烷 为溶剂， 以93%的产率得到[bis(η5-cyclopentadienyl)Ti(μ-O,P-diphenylphosphinoacetato)2(CuCl)2]
  参考文献：
  名称：

  Diphenylphosphinoacetate, nicotinate and thiophenoxyacetate as bridging ligands in heterometallic complexes involving bis(η-cyclopentadienyl)titanium(IV) and group 10 or 11 metal chlorides.

  摘要：

  Heterobi- and tri-metallic compounds containing a Cp2Ti(IV) unit linked via nicotinate, thiophenoxyacetate or diphenylphosphinoacetate ligands to Pd, Pt, Cu, Ag or An centres have been isolated. They are of the types [Cp2Ti{mu-OC(O)R}(2)MCl2] (M = Pd, R = m-C5H4N, CH2SPh and CH2PPh2; M = Pt, R = m-C5H4N or CH2PPh2), [Cp2Ti{mu-OC(O)CH2PPh2}(2)( M'Cl)(2)] (M' = Cu or Au) and [Cp2Ti{mu-OC(O)CH2PPh2}(2)AgCl]. The diphenylphosphinoacetate products arise both from methane elimination reactions of [Cp2TiMe2] with either [MCl2(Ph2PCH2CO2H)(2)] or [M'Cl(Ph2PCH2CO2H)] and from reactions of [Cp2Ti{mu-OC(O)CH2PPh2}(2)] with metal complexes containing labile ligands. Crystal structures of [Cp2Ti{OC(O)CH2PPh2}(2)] and [Cp2Ti{mu-OC(O)CH2PPh2}(2)PdCl2] are discussed. The latter compound contains diphenylphosphinoacetate groups which are O-unidentate with respect to titanium and P-unidentate with respect to palladium, the result being the formation of a ten-atom heterobimetallic ring system. (C) 2000 Elsevier Science Ltd All rights reserved.

  DOI：

  10.1016/s0277-5387(00)00305-3
• 作为产物：
  描述：

  dimethyltitanocene 、 羧基甲基二苯基膦 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 bis(η5-cyclopentadienyl)bis(O-diphenylphosphinoacetato)titanium(IV)
  参考文献：
  名称：

  有机金属二茂钛-金化合物作为肾癌的潜在化疗药物。其蛋白激酶抑制特性的研究

  摘要：

  早-晚过渡金属TiAu 2化合物[(η-C 5 H 5 ) 2 Ti{OC(O)CH 2 PPh 2 AuCl} 2 ] ( 3 )和新型[(η-C 5 H 5 ) 2 Ti{OC (O)-4-C 6 H 4 PPh 2 AuCl} 2 ] ( 5 ) 被评估为体外针对肾癌细胞系和前列腺癌细胞系的潜在抗癌剂。这些化合物在肾癌细胞中比单金属二氯化二茂钛和金(I) [{HOC(O)RPPh 2 }AuCl] (R = -CH 2 – 6 , -4-C 6 H 4 – 7 )衍生物更有效线，表明所得异金属物质的协同效应。对肾癌细胞系（纳摩尔范围内的5 种）的活性明显高于顺铂和高活性二茂钛 Y。体外Caki-1 细胞的初步机制研究及其在 35 个细胞上的抑制特性研究肿瘤学感兴趣的激酶表明这些化合物抑制 AKT 和 MAPKAPK 家族的蛋白激酶，对 MAPKAPK3 具有更高的选择性（IC 50 3

  DOI：

  10.1021/om500965k