potassium dichloro(pyridine-2-carboxylato)platinate(II) | 97069-24-4

• 英文名称: potassium dichloro(pyridine-2-carboxylato)platinate(II)
• 英文别名: K[PtCl2(picolinato-N,O)]；K[Pt(pic)Cl2]
• CAS: 97069-24-4
• 化学式: C₆H₄Cl₂NO₂Pt*K
• 分子量: 427.188
• InChiKey: CBUZGJWKVOAEQU-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  potassium dichloro(pyridine-2-carboxylato)platinate(II) 在 silver(I) acetate 作用下， 以 苯 为溶剂， 生成 铂
  参考文献：
  名称：

  Quantitative Assay for the Direct Comparison of Platinum Catalysts in Benzene H/D Exchange

  摘要：

  This paper describes a protocol for the direct comparison of diverse Pt catalysts in the H/D exchange between C6H6 and TFA-d(1), CD3CO2D, and TFE-d(3) using turnover number (TON) as a standard metric. An initial survey of Pt complexes, including commercial Pt salts (PtCl2, K2PtCl4) and Pt chloride complexes containing bidentate and tridentate nitrogen donor ligands, has been conducted. These studies have established that the addition of AgOAc (in TFA-d(1)) or AgBF4 (in CD3CO2D and TFE-d(3)) displaces the Cl ligands on the Pt precatalyst, which leads to dramatically increased turnover numbers, In general, PtCl2 and K2PtCl4 provided the fewest turnovers, and species containing bidentate ligands afforded higher turnover numbers than those with tridentate ligands. A diimine Pt complex was found to be a top performing catalyst for H/D exchange with all deuterium sources examined. Interestingly, the relative reactivity of many of the catalysts varied dramatically upon changing the deuterium source, highlighting the need tothoroughly assay potential catalysts under a variety of conditions.

  DOI：

  10.1021/om900495n
• 作为产物：
  描述：

  2-吡啶甲酸 、 potassium tetrachloroplatinate 以 N,N-二甲基甲酰胺 为溶剂， 以>80的产率得到potassium dichloro(pyridine-2-carboxylato)platinate(II)
  参考文献：
  名称：

  Annibale, Giuliano; Cattalini, Lucio; Chessa, Gavino, Gazzetta Chimica Italiana, 1985, vol. 115, # 5, p. 279 - 284

  摘要：

  DOI：

文献信息

• Pyridine-Carboxylate Complexes of Platinum. Effect of <i>N</i>,<i>O</i>-Chelate Formation on Model Bifunctional DNA−DNA and DNA−Protein Interactions
  作者：Susana M. O. Quintal、Yun Qu、Adorácion G. Quiroga、Joseph Moniodis、Helena I. S. Nogueira、Nicholas Farrell

  DOI：10.1021/ic050062w

  日期：2005.7.1

  This paper reports on the chemistry of platinum complexes containing bidentate pyridine-carboxylate (pyAc = pyridin-2-yl-acetate and picEt = pyridine-2-ethylcarboxylate, ethylpicolinate) (N,O) ligands. The pyridine-2-acetate and ethylpicolinate ligands form six- and five-membered chelates, respectively, upon formation of the Pt-carboxylate bond. In all reactions with picEt with various platinum complex starting materials, spontaneous de-esterification of the pendant carboxylate ester occurs to give directly the chelates K[PtCl2(pic-N,O)]-trans-[Pt(pic-N,O)(2)] and SP- 4,2-[PtCl(pic-N,O)(NH3)] without any evidence of intermediates. The de-esterification is solvent dependent, and molecular modeling was used to explain this reaction. The reactions of the geometric isomers of [PtCl(pyAc-N,O)(NH3)) with 5'-guanosine monophosphate, 5'-GMP, and N-acetyl-L-methionine, AcMet, were investigated by NMR spectroscopy. The objective was to ascertain by model chemistry the feasibility of formation of ternary DNA-Pt-protein adducts in biology. Model nucleotide and peptide compounds were formed in situ by chloride displacement giving (PtL(pyAc-N,O)(NH3)](+) (L = 5'-GMP or AcMet). Competitive reactions were then examined by addition of the complementary ligand L. Sulfur displacement of coordinated 5'-GMP was slow. For SP-4,3-[Pt(AcMet)(NH3)-(PyAc-N,O)](+), a rapid displacement of the sulfur ligand by 5'-GMP was observed, giving SP-4,2-[Pt(5'-GMP-N7)-(pyAc-N,O)(NH3)](+).
• Annibale, Giuliano; Cattalini, Lucio; Canovese, Luciano, Journal of the Chemical Society, Dalton Transactions, 1986, p. 1101 - 1106
  作者：Annibale, Giuliano、Cattalini, Lucio、Canovese, Luciano、Pitteri, Bruno、Tiripicchio, Antonio、et al.

  DOI：——

  日期：——
• Carboxylic Solvents and O-Donor Ligand Effects on CH Activation by Pt(II)
  作者：Vadim R. Ziatdinov、Jonas Oxgaard、Oleg A. Mironov、Kenneth J. H. Young、William A. Goddard、Roy A. Periana

  DOI：10.1021/ja060973k

  日期：2006.6.1

  We report on the design of more efficient C-H activation catalysts based on DFT calculations. The first examples of well-defined, N,O-donor ligated platinum complexes that are competent for fast C-H activation are detailed. These complexes exhibit thermal and protic stability and are efficient catalysts for H/D exchange reactions with benzene. The C-H activation is shown to benefit from design elements that (A) reduce the barrier for substrate coordination and (B) retain a low barrier for CH cleavage via a novel six-membered transition state involving the carboxylate group of the solvent.