trans-[PtCl4(N=C(Me)O-N(Me)-C(H)(Ph))2] | 267238-07-3

• 英文名称: trans-[PtCl4(N=C(Me)O-N(Me)-C(H)(Ph))2]
• 英文别名: trans-[PtCl4(N=C(Me)O-N(Me)-C(H)Ph)2]
• CAS: 267238-07-3；270064-62-5
• 化学式: C₂₀H₂₄Cl₄N₄O₂Pt
• 分子量: 689.328
• InChiKey: UWFHEOIUBAEREF-UTNKKNCOSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  trans-[PtCl4(N=C(Me)O-N(Me)-C(H)(Ph))2] 在 C₆H₅CH₂NHOH*HCl 、 NaHCO₃ 、 H₂O 作用下， 以 二氯甲烷 为溶剂， 以56%的产率得到trans-[PtCl2(N=C(Me)O-N(Me)-C(H)Ph)2]
  参考文献：
  名称：

  [2 + 3] Cycloaddition of Nitrones to Platinum-Bound Organonitriles:  Effect of Metal Oxidation State and of Nitrile Substituent

  摘要：

  The ligated benzonitriles in the platinum(II) complex [PtCl2(PhCN)(2)] undergo metal-mediated [2+3] cycloaddition with nitrones -ON+(R-3)=C(R-1)(R-2) [R-1/R-2/R-3 = H/Ph/Me, H/p-MeC6H4/Me, H/Ph/CH2Ph] to give Delta (4)-1,2,4-oxadiazoline complexes, [PtCl2{N=C(Ph)O-N(R-3)-C(R-1)(R-2)}(2)] (2a, 4a, 6a), as a 1:1 mixture of two diastereoisomers, in 60-75%, while [PtCl2(MeCN)(2)] is inactive toward the addition. However, a strong activation of acetonitrile was reached by application of the platinum(IV) complex [PtCl4(MeCN)(2)] and both [PtCl4(RCN)(2)] (R = Me, Ph) react smoothly with various nitrones to give [PtCl4{N=C(R)O-N(R-3)-C(R-1)(R-2)}(2)] (1b-6b). The latter were reduced to the corresponding platinum(II) complexes [PtCl2{N=C(R)O-N(R-3)-C(R-1)(R-2)}(2)] (1a-6a) exhibit different kinetic labilities, and liberation of the Delta (4)-1,2,4-oxadiazolines by substitution with 1,2-bis(diphenylphosphino)ethane (dppe) in CDCl3 proceeds at different rates to give free N=C(R)O-N(R-3)-C(R-1)(R-2) and [PtCl2(dppe)] in almost quantitative NMR yield. All prepared compounds were characterized by elemental analyses, FAB mass spectrometry, and IR and H-1, C-13{H-1}, and 195 Pt (metal complexes) NMR spectroscopies; X-ray structure determination of the first (Delta (4)-1,2,4-oxadiazoline)Pt(II) complexes was performed for (S,S)/(R,R)-rac-[PtCl2{N=C(Me)O-C(H)Ph-2}(2)] (1a) (a = 9.3562(4), b = 9.8046(3), c = 13.1146(5) Angstrom; alpha = 76.155(2), beta = 83.421(2), gamma = 73.285(2)degrees; V = 1117.39(7) Angstrom (3); triclinic P (1) over bar, Z = 2), (R,S)-meso-[PtCl2-(N=C(Ph)O-N(Me)-C(H)Ph)(2)] (2a) (a = 8.9689(9), b = 9.1365(5), c = 10.1846(10) Angstrom; alpha = 64.328(6), beta = 72.532(4), gamma = 67.744(6)degrees; V = 686.82(11) Angstrom (3); triclinic, P (1) over bar, Z = 1), (S,S)/(R,R)-rac-[PtCl2(N=C(Me)O-N(Me)-C(H)(p-C6H4Me))(2)] (3a) (a = 11.6378(2), b = 19.0767(7), c = 11.5782(40 Angstrom; beta = 111.062(2)degrees; V = 2398(13) Angstrom (3); monoclinic, P2(1)/c, Z = 4), and (S,S)/(R,R)-rac-[PtCl2(N=C(Me)O-N(CH2Ph)-C(H)Ph)-C(H)Ph-2] (5a) (a = 10.664(2), b = 10.879(2), c = 14.388(3) Angstrom; alpha = 73.11(3), beta = 78.30(3), gamma = 88.88(30 degrees; V = 1562.6(6) Angstrom (3); triclinic, P (1) over bar, Z = 2).

  DOI：

  10.1021/ic000477b
• 作为产物：
  描述：

  trans-[PtCl2(N=C(Me)O-N(Me)-C(H)Ph)2] 、 氯 以 氘代氯仿 为溶剂， 以99%的产率得到trans-[PtCl4(N=C(Me)O-N(Me)-C(H)(Ph))2]
  参考文献：
  名称：

  [2 + 3] Cycloaddition of Nitrones to Platinum-Bound Organonitriles:  Effect of Metal Oxidation State and of Nitrile Substituent

  摘要：

  The ligated benzonitriles in the platinum(II) complex [PtCl2(PhCN)(2)] undergo metal-mediated [2+3] cycloaddition with nitrones -ON+(R-3)=C(R-1)(R-2) [R-1/R-2/R-3 = H/Ph/Me, H/p-MeC6H4/Me, H/Ph/CH2Ph] to give Delta (4)-1,2,4-oxadiazoline complexes, [PtCl2{N=C(Ph)O-N(R-3)-C(R-1)(R-2)}(2)] (2a, 4a, 6a), as a 1:1 mixture of two diastereoisomers, in 60-75%, while [PtCl2(MeCN)(2)] is inactive toward the addition. However, a strong activation of acetonitrile was reached by application of the platinum(IV) complex [PtCl4(MeCN)(2)] and both [PtCl4(RCN)(2)] (R = Me, Ph) react smoothly with various nitrones to give [PtCl4{N=C(R)O-N(R-3)-C(R-1)(R-2)}(2)] (1b-6b). The latter were reduced to the corresponding platinum(II) complexes [PtCl2{N=C(R)O-N(R-3)-C(R-1)(R-2)}(2)] (1a-6a) exhibit different kinetic labilities, and liberation of the Delta (4)-1,2,4-oxadiazolines by substitution with 1,2-bis(diphenylphosphino)ethane (dppe) in CDCl3 proceeds at different rates to give free N=C(R)O-N(R-3)-C(R-1)(R-2) and [PtCl2(dppe)] in almost quantitative NMR yield. All prepared compounds were characterized by elemental analyses, FAB mass spectrometry, and IR and H-1, C-13{H-1}, and 195 Pt (metal complexes) NMR spectroscopies; X-ray structure determination of the first (Delta (4)-1,2,4-oxadiazoline)Pt(II) complexes was performed for (S,S)/(R,R)-rac-[PtCl2{N=C(Me)O-C(H)Ph-2}(2)] (1a) (a = 9.3562(4), b = 9.8046(3), c = 13.1146(5) Angstrom; alpha = 76.155(2), beta = 83.421(2), gamma = 73.285(2)degrees; V = 1117.39(7) Angstrom (3); triclinic P (1) over bar, Z = 2), (R,S)-meso-[PtCl2-(N=C(Ph)O-N(Me)-C(H)Ph)(2)] (2a) (a = 8.9689(9), b = 9.1365(5), c = 10.1846(10) Angstrom; alpha = 64.328(6), beta = 72.532(4), gamma = 67.744(6)degrees; V = 686.82(11) Angstrom (3); triclinic, P (1) over bar, Z = 1), (S,S)/(R,R)-rac-[PtCl2(N=C(Me)O-N(Me)-C(H)(p-C6H4Me))(2)] (3a) (a = 11.6378(2), b = 19.0767(7), c = 11.5782(40 Angstrom; beta = 111.062(2)degrees; V = 2398(13) Angstrom (3); monoclinic, P2(1)/c, Z = 4), and (S,S)/(R,R)-rac-[PtCl2(N=C(Me)O-N(CH2Ph)-C(H)Ph)-C(H)Ph-2] (5a) (a = 10.664(2), b = 10.879(2), c = 14.388(3) Angstrom; alpha = 73.11(3), beta = 78.30(3), gamma = 88.88(30 degrees; V = 1562.6(6) Angstrom (3); triclinic, P (1) over bar, Z = 2).

  DOI：

  10.1021/ic000477b

文献信息

• Platinum(IV)-Assisted [2 + 3] Cycloaddition of Nitrones to Coordinated Organonitriles. Synthesis of Δ⁴-1,2,4-Oxadiazolines
  作者：Gabriele Wagner、Armando J. L. Pombeiro、Vadim Yu. Kukushkin

  DOI：10.1021/ja993564f

  日期：2000.4.1

  [2 + 3] cycloaddition between acetonitrile ligands in the platinum(IV) complex [PtCl4(MeCN)(2)] and the nitrones -O+N(R-3)=C(R-1)(R-2) [R-1 = H, R-2 = Ph, sigma-C6H4OH, p-C6H4Me, p-C6H4OMe, p-C6H4NO2, p-C6H4NMe2, p-C6H4NMe2.HCl, R-3 = Me; R-1 = H, R-2 = Ph, 'Bu, R-3 = CH2Ph] proceeds smoothly under mild conditions and gives the first examples of Delta(4)-1,2,4-oxadiazoline complexes, [PtCl4(N=C(Me)O-N(R-3)-C)(R-1)(R-2)}(2)], as a 1:1 mixture of two diastereoisomers. in 70-90% yields. The heterocyclic ligands were liberated almost quantitatively by reaction at room temperature of the complexes with a slight excess of pyridine in chloroform giving free (N=C(Me)O-N(R-3)-C)(R-1)(R-2) and trans-[PtCl4(pyridine)(2)]; subsequent workup allowed the isolation of the novel Delta(4)-1,2,4-oxadiazolines. All prepared compounds were characterized by elemental analyses. FAB or EI mass spectrometry, and IR and H-1, C-13H-1}, and (195)pt (metal complexes) NMR spectroscopies: X-ray structure determination was performed for the (R,S) diastereoisomer of trans-[PtCl4(N=C(Me)ON(Me)-C)H(p-C6H4OMe)}(2)].