potassium trichloro(η2-methyleugenol)platinat(II) | 902783-02-2

• 英文名称: potassium trichloro(η2-methyleugenol)platinat(II)
• 英文别名: K[PtCl₃(4-allyl-1,2-dimethoxybenzene)]；K[PtCl₃(methyleugenol)]
• CAS: 902783-02-2
• 化学式: C₁₁H₁₄Cl₃O₂Pt*K
• 分子量: 518.768
• InChiKey: CEBNZIYXAYUMBC-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  potassium trichloro(η2-methyleugenol)platinat(II) 、 二乙胺 以 乙醇 、 水 为溶剂， 以70%的产率得到trans-dichloro(η2-methyleugenol)(diethylamine)platinum(II)
  参考文献：
  名称：

  Synthesis and spectral characterization of some complexes of platinum(II) containing η2-methyleugenol

  摘要：

  Several complexes of the formula trans-[Pt(Meug)(Am)Cl-2], Meug: methyleugenol (4-allyl-1,2-dimethoxybenzene), a eta(2)-coordinated olefin, and Am: ammine, methylamine, diethylamine, o-toluidine, m-toluidine, p-toluidine, o-anisidine, m-anisidine and p-anisidine have been prepared. UV, IR, Raman, H-1 NMR, C-13 NMR and 2D NMR spectra of the complexes were recorded and analyzed. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2007.03.017
• 作为产物：
  描述：

  甲基丁香酚 、 potassium trichloro(ethylene)platinate(II) 以 乙醇 为溶剂， 以80%的产率得到potassium trichloro(η2-methyleugenol)platinat(II)
  参考文献：
  名称：

  Synthesis and spectral characterization of some complexes of platinum(II) containing η2-methyleugenol

  摘要：

  Several complexes of the formula trans-[Pt(Meug)(Am)Cl-2], Meug: methyleugenol (4-allyl-1,2-dimethoxybenzene), a eta(2)-coordinated olefin, and Am: ammine, methylamine, diethylamine, o-toluidine, m-toluidine, p-toluidine, o-anisidine, m-anisidine and p-anisidine have been prepared. UV, IR, Raman, H-1 NMR, C-13 NMR and 2D NMR spectra of the complexes were recorded and analyzed. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2007.03.017

文献信息

• Synthesis, structure and properties of two series of platinum(II) complexes containing methyleugenol or chelating methyleugenol and amine
  作者：Tran Thi Da、Nguyen Thi Thanh Chi、Luc Van Meervelt、Peter Mangwala Kimpende、Nguyen Huu Dinh

  DOI：10.1016/j.poly.2014.08.045

  日期：2015.1

  Two series of platinum(II) complexes of the formula [PtCl2(Meug)(Amine)] (1-6, Meug: methyleugenol) and [PtCl(Meug-1H)(Amine)] (7-13, Meug-1H: deprotonated methyleugenol) were synthesized and characterized by elemental analyses, IR, H-1 NMR, C-13 NMR, NOESY and XRD spectra. In complexes 1-6 the methyleugenol ligand coordinates to Pt(II) through the ethylenic double bond of the allyl group, and the amine is in the trans-position in comparison to the ethylenic double bond. In complexes 7-13 the chelating methyleugenol ligand is bound to Pt(II) both through the ethylenic double bond of the allyl group and via an aromatic carbon. NOESY spectra and single-crystal X-ray diffraction of [PtCl(Meug-1H)(o-toluidine)] (14) indicate that in 7-14 the amines are in a cis-position with respect to the ethylenic double bond. [PtCl2(Meug)(Pyridine)] (4), [PtCl2(Meug)(Quinoline)] (5) and [PtCl(Meug-1H)(Quinoline)] (9) exhibit strong activities on human cancer cells KB with IC50 values of 3.7, 3.4 and 3.2 mu g/mL respectively. (C) 2014 Elsevier Ltd. All rights reserved.
• Synthesis, structure, and <i>in vitro</i> cytotoxicity of organoplatinum(II) complexes containing aryl olefins and quinolines
  作者：Tran Thi Da、Le Thi Hong Hai、Luc Van Meervelt、Nguyen Huu Dinh

  DOI：10.1080/00958972.2015.1068936

  日期：2015.10.2

  Ten new organoplatinum(II) complexes, [PtCl(Saf)(8-OQ)] (1), [Pt(Saf-1H)(8-OQ)] (2), [PtCl(Meug)(8-OQ)] (3), [Pt(Meug-1H)(8-OQ)] (4), [PtCl(Meteug)(8-OQ)] (5), [PtCl(Meteug)(Q)] (6), [Pt(Meteug)(Q-COO)] (7), [Pt(Eteug-1H)(Q)] (8), [Pt(Eteug-1H)(8-OQ)] (9), and [Pt(Eteug-1H)(Q-COO)] (10) (where Saf = safrole, Meug = methyleugenol, Meteug = methyl eugenoxyacetate, Eteug = ethyl eugenoxyacetate, Q = quinoline, 8-OQ = 8-hydroxyquinolinate, and Q-COO = quinolin-2-carboxylate), were synthesized and characterized by spectroscopic methods. The position of N and O donors of quinoline ligands in comparison with the ethylenic double bond and the aromatic C5 of the aryl olefins in platinum(II) coordination sphere of 1-10 was determined using their NOESY spectra and confirmed by single-crystal X-ray diffraction of 10. Complexes 1, 2, 3, 4, and 9 exhibit impressive activities on four human cancer cell lines KB, Hep-G2, Lu, and MCF7 with IC50 = 1.4-9.6 mu M. Complexes 1, 2, 4, and 9 gave better antitumor activity than cisplatin against examined cell lines.