[Pd(C6H3(CH2NH2)-2,F-5)(μ-Br)]2 | 187818-99-1

• 英文名称: [Pd(C6H3(CH2NH2)-2,F-5)(μ-Br)]2
• 英文别名: [Pd(C6H3CH2NH2-2-F-5)(μ-Br)]2
• CAS: 187818-99-1
• 化学式: C₁₄H₁₄Br₂F₂N₂Pd₂
• 分子量: 620.923
• InChiKey: DNOHANXNSFDDEK-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  3-己炔 、 [Pd(C6H3(CH2NH2)-2,F-5)(μ-Br)]2 以 丙酮 为溶剂， 以48%的产率得到[Pd(κ2(C,N)-C(Et)=C(Et)C(Et)=C(Et)C6H3-2-CH2NH2-5-F)Br]
  参考文献：
  名称：

  将一，二和三分子炔插入邻位钯化伯和仲芳烷基胺的Pd-C键中

  摘要：

  的邻位金属化配合物[钯2 {κ 2（C，N）-C 6 H ^ 4 CH 2 CH 2 NHMe-2} 2（μ-溴）2 ]（1）可通过一个回流1来制备：1混合物在乙腈中加入Pd（OAc）2和N-甲基苯乙胺，然后加入过量的NaBr。复杂1起反应以PPH 3，得到单核衍生物[钯{κ 2（C ^，Ñ）-C 6 H ^ 4 CH 2 CH 2NHMe-2} Br（PPh 3）]（2）。阳离子络合物[钯{κ 2（C ^，Ñ）-C 6 H ^ 4 CH 2 CH 2 NHMe-2}（PY）2 ] CLO 4（3）可通过反应而得到的1与AgClO 4和吡啶。先前报道的络合物[钯2 {κ 2（C，N）-C 6 H ^ 4 CH 2 NHCH 2 PH-2} 2（μ-溴）2 ]（甲）反应与PhC≡CCO 2 R（R = ME等），得到monoinserted衍生物[钯2 {κ 2（C ^，Ñ）-C（PH）= C（CO

  DOI：

  10.1021/om9002895
• 作为产物：
  描述：

  六(乙酸)三钯(II) 、 4-氟苄胺盐酸盐 、 sodium bromide 以 乙腈 为溶剂， 以69%的产率得到[Pd(C6H3(CH2NH2)-2,F-5)(μ-Br)]2
  参考文献：
  名称：

  Orthometalation of Primary Amines. 4.¹ Orthopalladation of Primary Benzylamines and (2-Phenylethyl)amine

  摘要：

  By the refluxing of an acetonitrile solution of [Pd(OAc)(2)](3) and primary amines 4-XC(6)H(4)CH(2)NH(2) (F, Cl, NO2, OMe), 3,5-X(2)C(6)H(3)CH(2)NH(2) (X = OMe), or PhCH(2)CH(2)NH(2) (Pd:amine = 1:1) and subsequent addition of excess NaBr, the corresponding orthometalated complexes [Pd{C6H3(CH2NH2)-2,X-5}(mu-Br)](2), [Pd{C6H3(CH2NH2)-2,(OMe)(2)-4,6}(mu-Br)](2), or [Pd{C6H3(CH2NH2)-2}(mu-Br)](2) are obtained. Alternatively, the hydrochloride of 4-XC(6)H(4)CH(2)NH(2) (X = F, NO2) can also be used to prepare the corresponding [Pd{C6H3(CH2NH2)-2,X-5}(mu-Cl)](2) complexes. These results show that primary benzylamines can be orthometalated even if the substituents are electron-withdrawing groups and that 2-(phenyl)ethylamine can be orthometalated in spite of the six-membered ring that it forms. These reactions occur via intermediate complexes [Pd(OAc)(2)L(2)], which react with [Pd(OAc)(2)](3) to give the dimeric species [Pd(OAc)(mu-OAc)L](2) (L = amine), from which in turn the orthometalated complexes are formed. Each of these steps has been studied, and both types of intermediates have been isolated for all the amines. PPh(3) reacts with the orthometalated complexes to give the corresponding products of the bridge splitting. The crystal structures of [Pd(OAc)(mu-OAc)L](2) (L = 4-O2NC6H4CH2NH2) and [Pd{C6H4(CH2CH2NH2)-2}Br(PPh(3))] have been determined by X-ray diffraction.

  DOI：

  10.1021/om9609574

文献信息

• Palladium-Assisted Formation of Carbon−Carbon Bonds. Part 10.¹ Insertion Reactions of Isocyanides into the Pd−C Bond of Orthopalladated Primary Amines. Synthesis of 2-R-Aminoisoindolinium Salts (R = ^tBu, 2,6-Xylyl)
  作者：José Vicente、Isabel Saura-Llamas、Claus Grünwald、Carmen Alcaraz、Peter G. Jones、Delia Bautista

  DOI：10.1021/om020365n

  日期：2002.8.19

  (1b), NO2 (1c), F (1d)] react with isocyanides (Pd:RNC = 1:1) to give [PdC6H3CH2NH2-2-X-5}Br(RNC)] [R = Xy = C6H3Me2-2,6, X = H (2a), OMe (2b), NO2 (2c), F (2d), R = tBu, X = H (3a), OMe (3b), NO2 (3c), F (3d)]. When XyNC reacts with 1a (Pd:RNC = 1:2) or with 2a (Pd:RNC = 1:1), the complex [Pd(CNXy)C6H4CH2NH2-2}(XyNC)Br] (4a) is obtained. The reactions of complexes 1 with isocyanides in the ratio Pd:RNC

  pal化的伯胺[Pd C 6 H 3 CH 2 NH 2 -2-X-5}（μ-Br）] 2 [X = H（1a），OMe（1b），NO 2（1c），F（1d）]与异氰化物（Pd：RNC = 1：1）反应，得到[Pd C 6 H 3 CH 2 NH 2 -2-X-5} Br（RNC）] [R = Xy = C 6 H 3 Me 2 -2,6，X = H（2a），OMe（2b），NO 2（2c），F（2d），R = tBu，X ＝ H（3a），OMe（3b），NO 2（3c），F（3d）]。当XyNC与1a（Pd：RNC = 1：2）或与2a（Pd：RNC = 1：1）反应时，络合物[Pd （C NXy）C 6 H 4 CH 2 NH 2 -2}（XyNC）得到Br]（4a）。配合物1与异氰酸酯的比例为Pd：RNC = 1：3的反应生成Pd（I）配合物[Pd 2 Br 2 L 4 ] [L