(4-bromo-3-cyclopropylisoquinolin-2-ium-2-yl)(tosyl)amide | 1112200-35-7

• 英文名称: (4-bromo-3-cyclopropylisoquinolin-2-ium-2-yl)(tosyl)amide
• CAS: 1112200-35-7
• 化学式: C₁₉H₁₇BrN₂O₂S
• 分子量: 417.326
• InChiKey: SAUFXDTYDZPJRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  (4-bromo-3-cyclopropylisoquinolin-2-ium-2-yl)(tosyl)amide 、 N,N'-二环己基碳二亚胺 以 二氯甲烷 、 乙腈 为溶剂， 生成 N-(((4-bromo-3-cyclopropylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Generation of diverse 1-(isoquinolin-1-yl)guanidines via a sequential multi-component/cross-coupling reaction

  摘要：

  A multi-component reaction of 2-alkynylbenzaldehyde, 4-methylbenzenesulfonohydrazide, carbodiimide, and bromine is reported, which generates 1-(4-bromoisoquinolin-1-yl)guanidines in good yields under mild conditions. The products could be further elaborated via a palladium-catalyzed Suzuki Miyaura coupling reaction, leading to the diverse 1-(isoquiriolin-1-yl)guanidines. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.081
• 作为产物：
  描述：

  对甲苯磺酰肼 在 三乙烯二胺 、 溴 作用下， 以 二氯甲烷 为溶剂， 反应 0.67h， 生成 (4-bromo-3-cyclopropylisoquinolin-2-ium-2-yl)(tosyl)amide
  参考文献：
  名称：

  Generation of diverse 1-(isoquinolin-1-yl)guanidines via a sequential multi-component/cross-coupling reaction

  摘要：

  A multi-component reaction of 2-alkynylbenzaldehyde, 4-methylbenzenesulfonohydrazide, carbodiimide, and bromine is reported, which generates 1-(4-bromoisoquinolin-1-yl)guanidines in good yields under mild conditions. The products could be further elaborated via a palladium-catalyzed Suzuki Miyaura coupling reaction, leading to the diverse 1-(isoquiriolin-1-yl)guanidines. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.081

文献信息

• Highly efficient electrophilic cyclization of N′-(2-alkynylbenzylidene)hydrazides
  作者：Qiuping Ding、Zhiyuan Chen、Xingxin Yu、Yiyuan Peng、Jie Wu

  DOI：10.1016/j.tetlet.2008.11.006

  日期：2009.1

  Electrophilic cyclization of N'-(2-alkynylbenzylidene)hydrazides with I-2, Br-2, or ICl under mild conditions is described. This reaction proceeds smoothly in dichloromethane at room temperature, which provides a useful method for the synthesis of functionalized isoquinolinium-2-yl amide. (C) 2008 Elsevier Ltd. All rights reserved.