| 872139-26-9

• CAS: 872139-26-9
• 化学式: C₁₇H₂₄FeN₂O
• 分子量: 328.237
• InChiKey: IGAKFZKHNFQKGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  、 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以33%的产率得到
  参考文献：
  名称：

  基于pH和硫醇的BODIPY响应型光敏剂，可用于靶向光动力疗法

  摘要：

  通过酸不稳定的缩酮和/或硫醇可裂解的二硫键将二碘二苯乙烯基二甲基吡啶二硼化（BODIPY）核心与两个二茂铁猝灭剂共轭，通过荧光诱导的电子转移过程显着淬灭了它们的荧光和光敏特性。包含缩酮或二硫键的两个对称类似物只能通过单一刺激激活，而非对称类似物对双重刺激有反应。与酸和/或二硫苏糖醇（DTT）相互作用后，这些接头被选择性切割。BODIPY核心和二茂铁基部分的分离恢复了前者在磷酸盐缓冲盐水和MCF-7乳腺癌细胞内部的光活性，使这些化合物成为潜在的可活化光敏剂，用于靶向光动力疗法。在酸性环境（pH 5）和DTT（4 mm）。与4 m m的DTT预孵育后，其对MCF-7细胞的光细胞毒性也增加了约两倍。该化合物的活化在携带HT29人结肠直肠癌的裸鼠中也得到证实。瘤内注射后9小时内观察到肿瘤中荧光强度的显着增加。

  DOI：

  10.1002/chem.201600452
• 作为产物：
  描述：

  (C5H5)Fe(C5H4)C(O)NH(CH2)6NHBOC 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  An integrated platform for the capture of circulating tumor cells and in situ SERS profiling of membrane proteins through rational spatial organization of multi-functional cyclic RGD nanopatterns

  摘要：

  建立了一个综合平台，通过多功能RGD纳米图案捕获癌细胞并进行HER2活性的SERS检测。

  DOI：

  10.1039/c8cc09108k

文献信息

• Stimuli‐Responsive Supramolecular Gelation in Ferrocene–Peptide Conjugates
  作者：Rouzbeh Afrasiabi、Heinz‐Bernhard Kraatz

  DOI：10.1002/chem.201302450

  日期：2013.12.16

  Teaching an old dog new tricks: Ferrocene–dipeptide conjugates capable of forming gels in response to various external signals including sound, thermal, redox, and mechanical stress are reported (see figure). Interesting examples of how ferrocene–peptide conjugates can be exploited for the construction of organometallic gelators are demonstrated.

  教老狗新的技巧：据报道，二茂铁-二肽结合物能够响应各种外部信号，包括声音，热，氧化还原和机械应力而形成凝胶（见图）。展示了如何利用二茂铁-肽共轭物构建有机金属胶凝剂的有趣例子。
• Cytotoxicity Induction by the Oxidative Reactivity of Nanoparticles Revealed by a Combinatorial GNP Library with Diverse Redox Properties
  作者：Shenqing Wang、Xiliang Yan、Gaoxing Su、Bing Yan

  DOI：10.3390/molecules26123630

  日期：——

  It is crucial to establish relationship between nanoparticle structures (or properties) and nanotoxicity. Previous investigations have shown that a nanoparticle’s size, shape, surface and core materials all impact its toxicity. However, the relationship between the redox property of nanoparticles and their toxicity has not been established when all other nanoparticle properties are identical. Here, by synthesizing an 80-membered combinatorial gold nanoparticle (GNP) library with diverse redox properties, we systematically explored this causal relationship. The compelling results revealed that the oxidative reactivity of GNPs, rather than their other physicochemical properties, directly caused cytotoxicity via induction of cellular oxidative stress. Our results show that the redox diversity of nanoparticles is regulated by GNPs modified with redox reactive ligands.

  建立纳米粒子结构（或性质）与纳米毒性之间的关系至关重要。先前的研究表明，纳米粒子的大小、形状、表面和核心材料都会影响其毒性。然而，在其他纳米粒子性质相同的情况下，纳米粒子的氧化还原性质与其毒性之间的关系尚未建立。通过合成一个包含80种不同氧化还原性质的金纳米粒子（GNP）库，我们系统地探索了这种因果关系。令人信服的结果显示，GNP的氧化反应性，而不是其其他物理化学性质，通过诱导细胞氧化应激直接导致细胞毒性。我们的结果表明，纳米粒子的氧化还原多样性受到具有氧化还原反应性配体修饰的GNP的调控。
• Electrochemical detection of kinase-catalyzed phosphorylation using ferrocene-conjugated ATP
  作者：Haifeng Song、Kagan Kerman、Heinz-Bernhard Kraatz

  DOI：10.1039/b714383d

  日期：——

  Adenosine-5′-[γ-ferrocene] triphosphate is exploited as a co-substrate for the phosphorylation of the surface-immobilized peptide C-SIYRRGSRRWRKL by protein kinase C, in which the γ-ferrocene phosphate is transferred to the peptide and then detected by cyclic voltammetry.

  利用腺苷-5′-[γ-二茂铁]三磷酸作为蛋白激酶 C 对表面固定肽 C-SIYRRGSRRWRKKL 进行磷酸化的辅助底物，在磷酸化过程中，γ-二茂铁被转移到肽上，然后通过循环伏安法进行检测。
• Self-Assembly of Amphiphilic Homopolymers Bearing Ferrocene and Carboxyl Functionalities: Effect of Polymer Concentration, β-Cyclodextrin, and Length of Alkyl Linker
  作者：Chun Feng、Guolin Lu、Yongjun Li、Xiaoyu Huang

  DOI：10.1021/la402335d

  日期：2013.8.27

  Three new acrylamide monomers containing ferrocene and tert-butyl ester groups were first synthesized via multistep nucleophilic substitution reaction under mild conditions followed by reversible addition fragmentation chain transfer (RAFT) homopolymerization to give well-defined homopolymers with narrow molecular weight distributions (M-w/M-n <= 1.36). The target amphiphilic homopolymers were obtained by the acidic hydrolysis of tert-butyoxycarbonyls to carboxyls in every repeating unit using CF3COOH. The self-assembly behaviors of these amphiphilic homopolymers bearing both ferrocene and carboxyl moieties in each repeating unit in aqueous media were investigated by transmission emission microscopy (TEM), dynamic light scattering (DLS), and atomic force microscopy (AFM). Large compound micelles with different morphologies were formed by these amphiphilic homopolymers, which consist of the corona formed by hydrophilic carboxyls and the core containing numerous reverse micelles with hydrophilic islands of carboxyls in continuous hydrophobic phase of ferrocene-based segments. The morphologies of the formed micelles could be tuned by the concentration of amphiphilic homopolymers, pH value of the solution, the length of -CH2 linker between ferrocene group and carboxyl, and the amount of beta-cyclodextrin (beta-CD).