Trigonopsis variabilis D-amino acid oxidase

• 英文名称: Trigonopsis variabilis D-amino acid oxidase

反应信息

• 作为试剂：
  描述：

  4-甲基茴香硫醚 在 Trigonopsis variabilis D-amino acid oxidase air 、 fungal peroxidase from Coprinus cinereus 、 DL-丙氨酸 作用下， 以 水 为溶剂， 反应 8.0h， 生成 (S)-(-)-甲基对甲苯亚砜
  参考文献：
  名称：

  Enantioselective synthesis of sulfoxides catalysed by an oxidase–peroxidase bienzymatic system

  摘要：

  We have devised a new bienzymatic oxidase-peroxidase system in which hydrogen peroxide is produced from air by a D-amino acid oxidase. The generated hydrogen peroxide is instantly used for asymmetric oxygenation of sulphides by a peroxidase. In the absence of peroxidase no spontaneous oxidation is observed, indicating that hydrogen peroxide production by the D-amino acid oxidase is fully controlled. Arylmethyl sulfoxides can be synthesised on a preparative scale with high yields and good enantiomeric excess. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00142-8