Thermobifida fusca phenylacenone monooxygenase

• 英文名称: Thermobifida fusca phenylacenone monooxygenase

反应信息

• 作为试剂：
  描述：

  2-(benzylthio)ethyl acetate 在 Thermobifida fusca phenylacenone monooxygenase 、 还原型辅酶II(NADPH)四钠盐 Α-D-吡喃葡萄糖6-磷酸 、 Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase 、 氧气 作用下， 反应 6.0h， 生成 2-[(S)-benzylsulfinyl]ethyl acetate 、 2-[(R)-benzylsulfinyl]ethyl acetate
  参考文献：
  名称：

  Oxidations catalyzed by phenylacetone monooxygenase from Thermobifida fusca

  摘要：

  Several organic sulfides, ketones and other organic systems have been tested as substrates in oxidation reactions catalyzed by the recently discovered phenylacetone monooxygenase from Thermobifida fusca. The biocatalytic properties of this Baeyer-Villiger monooxygenase have been studied, revealing reactivity with a large range of sulfides and ketones. Oxidations of several sulfoxides, an amine and an organoboron compound were also observed. The enzyme is able to oxidize a number of sulfides with excellent enantioselectivity, demonstrating the catalytic potential of this novel biocatalyst. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.08.004