2-((diisopropylphosphino)methyl)pyridine-borane complex | 1390625-60-1

• 英文名称: 2-((diisopropylphosphino)methyl)pyridine-borane complex
• CAS: 1390625-60-1
• 化学式: C₁₂H₂₃BNP
• 分子量: 223.106
• InChiKey: YVDOVNXQUSUHHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  tris(triphenylphosphine)ruthenium(II) chloride 、 2-((diisopropylphosphino)methyl)pyridine-borane complex 在 吗啉 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以27%的产率得到trans-[(trans-[(diisopropylphosphino(2-picolyl)phosphine)2RuCl₂])2RuCl₂]
  参考文献：
  名称：

  Catalytic hydrogenation of unactivated amides enabled by hydrogenation of catalyst precursor

  摘要：

  A general method for catalytic hydrogenation of unactivated amides was achieved. During the catalyst induction period, a novel structural change was observed involving full hydrogenation of the interior unsaturated bonds of the pyridines of the Ru-containing catalyst precursor. Based on this observation, the mechanism of amide hydrogenation may involve a two-step pathway, wherein the Ru catalyst having an H-Ru-N-H functionality is generated in the first step, followed by the amide carbonyl group interacting with the outer, rather than the inner, sphere of the Ru catalyst. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.03.047
• 作为产物：
  描述：

  氯二异丙基膦 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 8.5h， 生成 2-((diisopropylphosphino)methyl)pyridine-borane complex
  参考文献：
  名称：

  Catalytic hydrogenation of unactivated amides enabled by hydrogenation of catalyst precursor

  摘要：

  A general method for catalytic hydrogenation of unactivated amides was achieved. During the catalyst induction period, a novel structural change was observed involving full hydrogenation of the interior unsaturated bonds of the pyridines of the Ru-containing catalyst precursor. Based on this observation, the mechanism of amide hydrogenation may involve a two-step pathway, wherein the Ru catalyst having an H-Ru-N-H functionality is generated in the first step, followed by the amide carbonyl group interacting with the outer, rather than the inner, sphere of the Ru catalyst. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.03.047