1,1’-bis-{4-[methoxymethoxy]-3-[3’,5’-bis(trifluoromethyl)phenyl]phenyl}ferrocene | 1609243-31-3

• 英文名称: 1,1’-bis-{4-[methoxymethoxy]-3-[3’,5’-bis(trifluoromethyl)phenyl]phenyl}ferrocene
• CAS: 1609243-31-3
• 化学式: C₄₂H₃₀F₁₂FeO₄
• 分子量: 882.526
• InChiKey: MFQOCJAWVWOWJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1,1’-bis-{4-[methoxymethoxy]-3-[3’,5’-bis(trifluoromethyl)phenyl]phenyl}ferrocene 在 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 15.0h， 以96%的产率得到1,1'-bis-{4-hydroxy-3-[3',5'-bis(trifluoromethyl)phenyl]phenyl}ferrocene
  参考文献：
  名称：

  基于二茂铁桥联对环烷骨架的手性磷酸的开发

  摘要：

  AbstractThis work deals with the development of a new family of planar chiral phosphoric acids based on a ferrocenophane/paracyclophane scaffold. The synthetic approach has been improved by taking advantage of a chiral phosphorylating agent to access enantiomerically enriched acids via diastereomers separation. These phosphoric acids have been used as catalysts for the enantioselective H‐transfer reduction of α‐substituted quinolines with Hantzsch esters. Optimization of both the catalyst and the Hantzsch reductant allowed ee values in the range 82–92% to be attained starting from α‐arylquinolines.magnified image

  DOI：

  10.1002/adsc.201300697
• 作为产物：
  描述：

  3,5-双三氟甲基溴苯 、 1,1’-bis[4-(methoxymethoxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-phenyl]ferrocene 在 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 18.0h， 以94%的产率得到1,1’-bis-{4-[methoxymethoxy]-3-[3’,5’-bis(trifluoromethyl)phenyl]phenyl}ferrocene
  参考文献：
  名称：

  基于二茂铁桥联对环烷骨架的手性磷酸的开发

  摘要：

  AbstractThis work deals with the development of a new family of planar chiral phosphoric acids based on a ferrocenophane/paracyclophane scaffold. The synthetic approach has been improved by taking advantage of a chiral phosphorylating agent to access enantiomerically enriched acids via diastereomers separation. These phosphoric acids have been used as catalysts for the enantioselective H‐transfer reduction of α‐substituted quinolines with Hantzsch esters. Optimization of both the catalyst and the Hantzsch reductant allowed ee values in the range 82–92% to be attained starting from α‐arylquinolines.magnified image

  DOI：

  10.1002/adsc.201300697