2-Methyl-pyrazolo<3,4-b>-pyrazin | 21616-65-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并[3,4-b]吡嗪
• 英文名称: 2-Methyl-pyrazolo<3,4-b>-pyrazin
• 英文别名: 2H-Pyrazolo[3,4-b]pyrazine, 2-methyl-；2-methylpyrazolo[3,4-b]pyrazine
• CAS: 21616-65-9
• 化学式: C₆H₆N₄
• 分子量: 134.14
• InChiKey: HKYBFXRUDZMDNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF<br/>[FR] STÉROÏDES NEUROACTIFS, COMPOSITIONS ET UTILISATIONS
  申请人：SAGE THERAPEUTICS INC

  公开号：WO2015027227A1

  公开（公告）日：2015-02-26

  Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R1, R2, R5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

  本文描述了化学式（I）中的神经活性类固醇或其药用可接受盐；其中-------，R1，R2，R5，A和L如本文所定义。在某些实施例中，预期这些化合物将表现为GABA调节剂。本发明还提供了包括本发明化合物的药物组合物以及使用和治疗方法，例如用于诱导镇静和/或麻醉的方法。
• [EN] COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS<br/>[FR] COMPOSITIONS ET MÉTHODES POUR TRAITER DES TROUBLES DU SNC
  申请人：SAGE THERAPEUTICS INC

  公开号：WO2016061527A1

  公开（公告）日：2016-04-21

  Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein (II), A, R1, R2, R3a, R4a, R4b, R5, R7a, and R7b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

  本文描述了式(I)的神经活性类固醇，或其药用可接受盐；其中(II)，A，R1，R2，R3a，R4a，R4b，R5，R7a和R7b如本文所定义。在某些实施例中，这些化合物被设想为GABA调节剂。本发明还提供了包括本发明化合物的药物组合物，以及使用和治疗方法，例如用于诱导镇静和/或麻醉。
• NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
  申请人：SAGE THERAPEUTICS, INC.

  公开号：US20160229887A1

  公开（公告）日：2016-08-11

  Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R 1 , R 2 , R 5 , A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

  本文描述了式(I)的神经活性类固醇或其药学上可接受的盐；其中-------，R1，R2，R5，A和L的定义如下。在某些实施方式中，这些化合物被认为是GABA调节剂。本发明还提供了包含本发明化合物的制药组合物以及使用和治疗方法，例如用于诱导镇静和/或麻醉。
• PREPARATION AND APPLICATION OF CLASS OF N-CONTAINING HETEROCYCLIC COMPOUNDS HAVING IMMUNOREGULATORY FUNCTION
  申请人：Shanghai Ennovabio Pharmaceuticals Co., Ltd.

  公开号：EP3831824A1

  公开（公告）日：2021-06-09

  The present invention discloses the preparation and application of heterocyclic compound having immunoregulatory function. Specifically, the present invention discloses a compound having a structure according to Formula I, wherein the definition of each group is as described in the specification. The invention also provides the use of the compounds in regulating immunity and inhibiting PD-1/PD-L1.

  本发明公开了具有免疫调节功能的杂环化合物的制备和应用。具体而言，本发明公开了一种具有符合式 I 结构的化合物，其中各基团的定义如说明书所述。本发明还提供了该化合物在调节免疫和抑制 PD-1/PD-L1 方面的用途。
• A COMPOUND, COMPOSITIONS THEREOF AND THIS COMPOUND FOR USE IN METHODS OF TREATING CNS DISORDERS
  申请人：Sage Therapeutics, Inc.

  公开号：EP3885352A1

  公开（公告）日：2021-09-29

  The present invention relates to the compound of the formula given below or a pharmaceutically acceptable salt thereof. This compound is envisioned, in certain embodiments, to behave as a GABA modulator. The present invention also provides pharmaceutical compositions comprising the compound of the present invention and also provides this compound for use in methods of treatment, such as for inducing sedation and/or anesthesia.

  本发明涉及下式化合物或其药学上可接受的盐。在某些实施方案中，该化合物被设想为 GABA 调节剂。本发明还提供了包含本发明化合物的药物组合物，并提供了该化合物用于治疗方法，如诱导镇静和/或麻醉。