10-(4-(bis(2-((2-methoxy-2-oxoethyl)thio)ethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-3H-5l5-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-3-ide | 1202380-86-6

• 英文名称: 10-(4-(bis(2-((2-methoxy-2-oxoethyl)thio)ethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-3H-5l5-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-3-ide
• CAS: 1202380-86-6
• 化学式: C₂₉H₃₆BF₂N₃O₄S₂
• 分子量: 603.562
• InChiKey: FFPHPUNSTADEHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  10-(4-(bis(2-((2-methoxy-2-oxoethyl)thio)ethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-3H-5l5-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-3-ide 在 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 以71%的产率得到10-(4-(bis(2-((carboxymethyl)thio)ethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-3H-5l5-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-3-ide
  参考文献：
  名称：

  A Turn-On Fluorescent Sensor for Detecting Nickel in Living Cells

  摘要：

  We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni2+ in aqueous solution and in living cells. NS1 combines a BODIPY chromophore and a mixed N/O/S receptor to provide good selectivity for Ni2+ over a range of biologically abundant metal ions in aqueous solution. In addition to these characteristics, confocal microscopy experiments further show that NS1 can be delivered into living cells and report changes in intracellular Ni2+ levels in a respiratory cell model.

  DOI：

  10.1021/ja906500m
• 作为产物：
  描述：

  2,4-二甲基吡咯 、 dimethyl 2,2'-((((4-formylphenyl)azanediyl)bis(ethane-2,1-diyl))bis(sulfanediyl))diacetate 在 三氟乙酸 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 以38%的产率得到10-(4-(bis(2-((2-methoxy-2-oxoethyl)thio)ethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-3H-5l5-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-3-ide
  参考文献：
  名称：

  A Turn-On Fluorescent Sensor for Detecting Nickel in Living Cells

  摘要：

  We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni2+ in aqueous solution and in living cells. NS1 combines a BODIPY chromophore and a mixed N/O/S receptor to provide good selectivity for Ni2+ over a range of biologically abundant metal ions in aqueous solution. In addition to these characteristics, confocal microscopy experiments further show that NS1 can be delivered into living cells and report changes in intracellular Ni2+ levels in a respiratory cell model.

  DOI：

  10.1021/ja906500m