Boc-(Lys(Boc))10-OH | 90522-20-6

• 英文名称: Boc-(Lys(Boc))10-OH
• CAS: 90522-20-6
• 化学式: C₁₁₅H₂₁₀N₂₀O₃₃
• 分子量: 2401.05
• InChiKey: BKETYXPAPOWMHQ-HMGXWQPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.28
• 重原子数：
  168.0
• 可旋转键数：
  70.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  720.83
• 氢给体数：
  21.0
• 氢受体数：
  32.0

反应信息

• 作为产物：
  描述：

  Boc-(Lys(Boc))10-4-(hydroxymethyl)benzyl 3β-cholestanyl succinate 在 钯 氢气 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 反应 14.0h， 以84%的产率得到Boc-(Lys(Boc))10-OH
  参考文献：
  名称：

  Potentiation of the tolerogenicity of benzylpenicilloylated eicosa-L-lysine by conjugation with 4-methoxybenzyl 3.beta.-cholestanyl succinate

  摘要：

  It was previously found that amino acid polymers such as oligolysines bearing haptenic groups in high densities efficiently suppress anti-hapten IgE antibody formation. Such conjugates are strong elicitors of anaphylaxis and therefore may not be used for desensitization of drug allergic patients. Here we report on the synthesis and immunological evaluation of benzylpenicilloylated (BPO) eicosa-L-lysines containing none, one, or two lipophilic p-(hydroxymethyl)benzyl cholestan-3 beta-yl succinate (OSuco) groups. The lipophilic derivatives suppress primary as well as ongoing anti-BPO IgE antibody formation in mice much more efficiently than their hydrophilic counterpart. The lipophilic but not the hydrophilic derivatives form stable micelles in water and suppress the antibody formation according to different cellular mechanisms. The relationship between structure, hydrophobicity, and mode of action is discussed.

  DOI：

  10.1021/jm00377a020