[Cp₂Mo(D-penicillamine)]Cl | 1571098-28-6

• 英文名称: [Cp₂Mo(D-penicillamine)]Cl
• 英文别名: [Cp₂Mo(ethyl maltolato)]Cl
• CAS: 1571098-28-6
• 化学式: C₁₇H₁₇MoO₃*Cl
• 分子量: 400.713
• InChiKey: PBMXGOXNYZGZRQ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  二氯二茂钼 、 乙基麦芽酚 在 sodium hydroxide 作用下， 以 水 为溶剂， 以60%的产率得到[Cp₂Mo(D-penicillamine)]Cl
  参考文献：
  名称：

  Water soluble molybdenocene complexes: Synthesis, cytotoxic activity and binding studies to ubiquitin by fluorescence spectroscopy, circular dichroism and molecular modeling

  摘要：

  Four new molybdenocene complexes, Cp2Mo(L-ascorbato), Cp2Mo(6-O-palmitoyl-L-ascorbato), [Cp2Mo(ethyl maltolato)]Cl and Cp2Mo((2S)-2-amino-3-methyl-3-thiolato-butanoato), were synthesized and structurally characterized by standard analytical methods. The cytotoxicity of these complexes was assessed on colon HT-29 and breast MCF-7 cancer cell lines using the 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide (MTT) assay. A higher cytotoxic activity was shown by all the new complexes on the MCF-7 cells over the Cp2MoCl2 complex. The complexes Cp2Mo(L-ascorbato), Cp2Mo(6-O-palmitoyl-L-ascorbato) and [Cp2Mo(ethyl maltolato)]Cl displayed a stronger cytotoxic activity on colon cancer HT-29 cell line, over the molybdenocene dichloride (Cp(2)MoCl2). In contrast, Cp2Mo((2S)-2-amino-3-methyl-3-thiolato-butanoato) exhibited proliferative properties on this cell line. Ubiquitin (Ub)-molybdenocene interactions were investigated using cyclic voltammetry, fluorescence quenching spectroscopy, circular dichroism (CD) and molecular modeling. The thermodynamic parameters (Delta H and Delta S) obtained using fluorescence quenching spectra and van't Hoff plot indicate the Ub-molybdenocene interactions are mainly hydrophobic. The CD data also support hydrophobic interactions with conformational changes in the Ub protein. Docking studies using molecular modeling revealed the amino adds involved in the Ub-molybdenocene interactions and corroborated the hydrophobic nature of the binding combined with hydrogen bonding. (C) 2013 Elsevier Inc All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2013.10.014