| 1101835-31-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1101835-31-7
• 化学式: C₂₀H₂₅N₃O₉
• 分子量: 451.433
• InChiKey: DQHAFTYOEMXUNS-DEPCRRQNSA-N

反应信息

• 作为反应物：
  描述：

  苯酐 、 在 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 以74%的产率得到2-[[(2S,3S,4S,5S,6S)-4,5-diacetyloxy-2-(acetyloxymethyl)-6-(2,5-dimethoxyphenyl)oxan-3-yl]carbamoyl]benzoic acid
  参考文献：
  名称：

  β-C-Glycosiduronic acids and β-C-glycosyl compounds: New PTP1B inhibitors

  摘要：

  beta-C-Glycosiduronic acid quinones and beta-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl beta-C-glycosyl compounds (18, 22, 23 and 34) showed IC50 values of 0.77-5.27 mu M against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.091
• 作为产物：
  描述：

  在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以71%的产率得到
  参考文献：
  名称：

  β-C-Glycosiduronic acids and β-C-glycosyl compounds: New PTP1B inhibitors

  摘要：

  beta-C-Glycosiduronic acid quinones and beta-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl beta-C-glycosyl compounds (18, 22, 23 and 34) showed IC50 values of 0.77-5.27 mu M against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.091