| 1609461-08-6

• CAS: 1609461-08-6
• 化学式: C₁₇H₂₈ClN₃O₂PRh
• 分子量: 475.76
• InChiKey: ZPYHHEIONQMAPC-ONEVTFJLSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane 、 chloro(1,5-cyclooctadiene)rhodium(I) dimer 以 四氢呋喃 为溶剂， 反应 1.5h， 以83%的产率得到
  参考文献：
  名称：

  Exploring Rhodium(I) Complexes [RhCl(COD)(PR₃)] (COD = 1,5-Cyclooctadiene) as Catalysts for Nitrile Hydration Reactions in Water: The Aminophosphines Make the Difference

  摘要：

  Several rhodium(I) complexes, [RhCl(COD)-(PR3)], containing potentially cooperative phosphine ligands, have been synthesized and evaluated as catalysts for the selective hydration of organonitriles into amides in water. Among the different phosphines screened, those of general composition P(NR2)(3) led to the best results. In particular, complex [RhCl(COD){P(NMe2)(3)}] was able to promote the selective hydration of a large range of nitriles in water without the assistance of any additive, showing a particularly high activity with heteroaromatic and heteroaliphatic substrates. Employing this catalyst, the antiepileptic drug rufinamide was synthesized in high yield by hydration of 4-cyano-1-(2,6-difluorobenzyl)-1H-1,2,3-triazole. For this particular transformation, complex [RhCl(COD){P(NMe2)(3)}] resulted more effective than related ruthenium catalysts.

  DOI：

  10.1021/cs500241p