苯,[(5,5-二氟戊基)氧代]- | 220322-86-1

• 中文名称: 苯,[(5,5-二氟戊基)氧代]-
• 英文名称: Manganese(3+) chloride 5,10,15,20-tetrakis(4-aminophenyl)porphine-21,23-diide (1:1:1)
• 英文别名: 5,10,15,20-tetrakis(4-aminophenyl)-porphyrinatomanganese(III) chloride；5,10,15,20-tetrakis(4-aminophenyl)porphyrinatomanganese(III) chloride；5,10,15,20-tetrakis(p-aminophenyl)porphyrinatomanganese chloride；tetrakis(p-aminophenyl)porphyrinatomanganese(III) chloride；4-[(5Z,10Z,14Z,19Z)-10,15,20-tris(4-aminophenyl)-21,23-dihydroporphyrin-5-yl]aniline-manganese(III) chloride
• CAS: 220322-86-1；97972-81-1
• 化学式: C₄₄H₃₂ClMnN₈
• 分子量: 763.183
• InChiKey: XMZSNBDFOUWBIZ-YKKPBKTHSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  苯,[(5,5-二氟戊基)氧代]- 、 formylmethyltriphenylphosphonium bromide 在 sodium chloride 作用下， 以 二甲基亚砜 、 水 为溶剂， 反应 1.0h， 以2.7 mg的产率得到triphenyl[(2E)-2-[4-[(1Z,4Z,9Z,15Z)-10,15,20-tris(4-aminophenyl)-21,23-dihydroporphyrin-5-yl]phenyl]iminoethyl]phosphornium-manganese(III) dichloride
  参考文献：
  名称：

  A Manganese–Porphyrin Complex Decomposes H₂O₂, Inhibits Apoptosis, and Acts as a Radiation Mitigator in Vivo

  摘要：

  Ionizing radiation triggers mitochondria] overproduction of H2O2 with concomitant induction of intrinsic apoptosis, whereby clearance of H2O2 upon overexpression of mitochondrial catalase increases radioresistance in vitro and in vivo. As an alternative to gene therapy, we tested the potential of Mn-(III)-porphyrin complexes to clear mitochondrial H2O2. We report that triphenyl[(2E)-2-[4- [(1Z,4Z,9Z,15Z)-10,15,20-tris(4-aminophenyl)-21,23-dihydroporphyrin-5-yl]phenyl]iminoethyl]phosphonium-Mn-(III) compartmentalizes preferentially into mitochondria of mouse embryonic cells, reacts with H2O2, impedes gamma-ray-induced mitochondrial apoptosis, and increases the survival of mice exposed to whole body irradiation with gamma-rays.

  DOI：

  10.1021/ml200142x
• 作为产物：
  描述：

  tetrakis(4-aminophenyl)porphyrin 在 manganese(II) acetate 、 sodium chloride 作用下， 以 异丙醇 、 水 为溶剂， 反应 6.5h， 以92%的产率得到苯,[(5,5-二氟戊基)氧代]-
  参考文献：
  名称：

  A Manganese–Porphyrin Complex Decomposes H₂O₂, Inhibits Apoptosis, and Acts as a Radiation Mitigator in Vivo

  摘要：

  Ionizing radiation triggers mitochondria] overproduction of H2O2 with concomitant induction of intrinsic apoptosis, whereby clearance of H2O2 upon overexpression of mitochondrial catalase increases radioresistance in vitro and in vivo. As an alternative to gene therapy, we tested the potential of Mn-(III)-porphyrin complexes to clear mitochondrial H2O2. We report that triphenyl[(2E)-2-[4- [(1Z,4Z,9Z,15Z)-10,15,20-tris(4-aminophenyl)-21,23-dihydroporphyrin-5-yl]phenyl]iminoethyl]phosphonium-Mn-(III) compartmentalizes preferentially into mitochondria of mouse embryonic cells, reacts with H2O2, impedes gamma-ray-induced mitochondrial apoptosis, and increases the survival of mice exposed to whole body irradiation with gamma-rays.

  DOI：

  10.1021/ml200142x

文献信息

• Encapsulation of Flavin Cofactor within a Manganese Porphyrin-Based Metal–Organic Polyhedron for Reductive Dioxygen Activation
  作者：LiLi Li、Huimin Guo、Linlin Yang、Xuezhao Li、Hailing Wang、Cheng He

  DOI：10.1021/acs.inorgchem.9b03430

  日期：2020.3.2

  (NADH). This supramolecular system was capable of efficiently activating dioxygen and catalyzing the oxidation of benzyl alcohol. Control experiments suggested that the close proximity between FMN and manganese(III) porphyrins forced by the host-guest interaction might benefit the electron-transfer process from the FMN cofactor to the metal centers.

  在基于卟啉锰（III）的立方笼中封装黄素单核苷酸（FMN），可以在存在烟酰胺腺嘌呤二核苷酸（NADH）的情况下快速还原锰（III）卟啉。该超分子系统能够有效地活化双氧并催化苯甲醇的氧化。对照实验表明，FMN与主体-客体相互作用所强迫的锰（III）卟啉之间的紧密距离可能有益于从FMN辅因子到金属中心的电子转移过程。
• Synthesis and characterization of a new porphyrin–polyoxometalate hybrid material and investigation of its catalytic activity
  作者：Mehdi Araghi、Valiollah Mirkhani、Majid Moghadam、Shahram Tangestaninejad、Iraj Mohammdpoor-Baltork

  DOI：10.1039/c2dt11865c

  日期：——

  material in which tetrakis(p-aminophenylporphyrin) is covalently linked to a Lindqvist structure of polyoxometalate, is reported. This new porphyrin–polyoxometalate hybrid material was characterized by 1H NMR, FT-IR and UV-Vis spectroscopic methods and cyclic voltammetry. These spectro- and electrochemical studies provided spectral data of the synthesis of this compound. Cyclic voltammetry showed the influence

  在目前的工作中，报道了一种新的有机-无机杂化材料的制备，其中四（对氨基苯基卟啉）与多金属氧酸盐的Lindqvist结构共价连接。这种新型的卟啉-多金属氧酸盐杂化材料通过1 H NMR，FT-IR和UV-Vis光谱法以及循环伏安法进行了表征。这些光谱和电化学研究提供了该化合物合成的光谱数据。循环伏安法显示了卟啉对多金属氧酸盐的氧化还原过程的影响。在NaIO 4的烯烃环氧化中研究了这种杂化材料的催化活性。
• Impregnation of metal ions into porphyrin-based imine gels to modulate guest uptake and to assemble a catalytic microfluidic reactor
  作者：Lihua Zeng、Peisen Liao、Haoliang Liu、Liping Liu、Ziwei Liang、Jianyong Zhang、Liuping Chen、Cheng-Yong Su

  DOI：10.1039/c6ta01035k

  日期：——

  A series of (metallo)porphyrin imine gels have been synthesized based on imine chemistry. The resulting aerogels have sponge-like porous networked structures consisting of interconnected nanoparticles with hierarchical porosity. The aerogels have high specific surface areas (up to 719 m2 g−1) and large pore volumes (up to 2.60 cm3 g−1). The effect of metal ions on the uptake of gases in these aerogels

  基于亚胺化学合成了一系列的（金属）卟啉亚胺凝胶。所得的气凝胶具有海绵状的多孔网络结构，该结构由具有分层孔隙率的相互连接的纳米颗粒组成。气凝胶具有高的比表面积（高达719 m 2 g -1）和大的孔体积（高达2.60 cm 3 g -1）。研究了金属离子对这些气凝胶中气体吸收的影响。浸渍各种金属离子（Pd（II），Ni（II），Mn（III），Fe（III）和Sn（IV））可提高各种气体（例如CO 2）的吸收能力），尽管它们的密度较高。在金属离子中，Pd（Ⅱ）是提高CO 2吸附容量和等排热的最佳选择。所述的Pd-TAPP-A4气凝胶显示出CO 2的体积的吸收（1.62毫摩尔克-1，在298 K，1巴7.13重量％）与吸附的高等量吸附热（40.0千焦摩尔-1）。由于其独特的分级孔隙率和金属中心的可用性，这些凝胶还显示出在催化中的潜在应用。结合微流体技术，已将催化凝胶毛细管反应器组装在一起，而P