| 19538-46-6

• CAS: 19538-46-6
• 化学式: C₄₈H₃₆Fe₂N₄O₅
• 分子量: 860.532
• InChiKey: PFNRHRPXGICFCS-RMHZUEAHSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  乙二胺 、 2-羟基-1-萘甲醛 、 iron (III) chloride hexahydrate 以 甲醇 为溶剂， 以70%的产率得到
  参考文献：
  名称：

  Zelentsov, Russian Journal of Coordination Chemistry, 1998, vol. 24, # 4, p. 295 - 299

  摘要：

  DOI：

文献信息

• Evaluation of photochemotherapeutic potential of a few oxo-bridged dimeric Fe(III) compounds having Salen-type ligands
  作者：Dhananjay Das、Md Kausar Raza、Tridib K. Goswami

  DOI：10.1016/j.poly.2020.114614

  日期：2020.8

  Four oxo-bridged dimeric Fe(III) complexes, viz. [(mu-O)Fe(L)}(2)] (1-4), where L is N,N '-bis(naphtalidene)ethylenediamine, (H2L1 in 1); N,N '-bis(naphtalidene)-1,2-phenylenediamine, (H2L2 in 2); N,N '-bis(naphtalidene)-4-nitro-1,2-phenylenediamine (H2L3 in 3) and N,N '-bis(naphtalidene)-4-carboxyl-1,2-phenylenediamine, (H2L4 in 4) were synthesized for their potential application as photochemotherapeutic agents in low energy visible light. The solid-state structure of complex 2 was confirmed by X-ray crystallography. The complexes bind to human serum albumin (HSA) reversibly in a pH dependent manner, which could be a potential carrier of the molecules in blood plasma. They also bind to calf-thymus (ct) DNA with considerable affinity. In vitro cellular experiments show that the complexes display significant photo-enhanced cytotoxicity in human cervical cancer (HeLa) and human breast cancer (MCF-7 and MDA-MB-231) cells with low dark toxicity. ICP-MS analysis show that the complexes enter HeLa cells in a dose-dependent manner. Flow cytometric and confocal microscopic experiments demonstrate that the complexes kill cancer cells on exposure to visible light primarily via apoptosis through the generation of reactive oxygen species (ROS). (C) 2020 Elsevier Ltd. All rights reserved.