4-[5-(benzyloxy)-2-bromophenoxymethyl]pyridine | 1372147-57-3

• 英文名称: 4-[5-(benzyloxy)-2-bromophenoxymethyl]pyridine
• 英文别名: 4-((5-(Benzyloxy)-2-bromophenoxy)methyl)pyridine；4-[(2-bromo-5-phenylmethoxyphenoxy)methyl]pyridine
• CAS: 1372147-57-3
• 化学式: C₁₉H₁₆BrNO₂
• 分子量: 370.246
• InChiKey: LZRBQDMZEFXAAV-UHFFFAOYSA-N

物化性质

• 沸点：
  502.7±45.0 °C(Predicted)
• 密度：
  1.380±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[5-(benzyloxy)-2-bromophenoxymethyl]pyridine 在 sodium tetrahydroborate 、 potassium hydrogencarbonate 作用下， 以 甲醇 、 二氯甲烷 、 丙酮 为溶剂， 反应 44.0h， 生成 benzyl 4-[5-(benzyloxy)-2-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine-1-carboxylate
  参考文献：
  名称：

  Synthesis of novel 2H-spiro[1-benzofuran-3,4′-piperidin]ol scaffolds

  摘要：

  With the aim to enrich our 'privileged structure'-based library, novel 2H-spiro[1-benzofuran-3,4'-piperidin]ol scaffolds were prepared. The method involved a key intramolecular Heck cyclization which was successfully applied for three series of compounds. The desired scaffolds were obtained in overall yields of 42-53%. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.03.005
• 作为产物：
  描述：

  4-吡啶甲醇 、 4-(苄氧基)-1-溴-2-氟苯 在 sodium hydride 作用下， 以 N-甲基吡咯烷酮 、 mineral oil 为溶剂， 反应 2.5h， 以83%的产率得到4-[5-(benzyloxy)-2-bromophenoxymethyl]pyridine
  参考文献：
  名称：

  Synthesis of novel 2H-spiro[1-benzofuran-3,4′-piperidin]ol scaffolds

  摘要：

  With the aim to enrich our 'privileged structure'-based library, novel 2H-spiro[1-benzofuran-3,4'-piperidin]ol scaffolds were prepared. The method involved a key intramolecular Heck cyclization which was successfully applied for three series of compounds. The desired scaffolds were obtained in overall yields of 42-53%. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.03.005