| 1536470-51-5

• CAS: 1536470-51-5
• 化学式: C₂₂H₃₆Li₂N₂O₄
• 分子量: 406.421
• InChiKey: WBDMCXNIRLFBBS-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  正丁基锂 、 乙二醇二甲醚 、 N-甲基苯胺 生成
  参考文献：
  名称：

  Structures of Lithium N-Monosubstituted Anilides: Trisolvated Monomer to Tetrasolvated Dimer

  摘要：

  Crystal structure determination of lithiated N-methylaniline with a variety of ligands, including tetrahydrofuran, methyltetrahydrofuran, trans-2,5-dimethyltetrahydrofuran, dimethoxyethane, tetrahydropyran and N,N-diethylpropionamide, reveals a common Li-N-Li-N four-membered-ring dimeric structure motif. A progression of solvation from tetrasolvated dimer (PhNMeLi center dot S-2)(2) through trisolvated dimer to disolvated dimer (PhNMeLi center dot S)(2) was observed by increasing the steric hindrance of the ligand. Solid-state structures of several other lithium N-alkylanilides solvated by tetrahydrofuan are also reported. When the methyl group of N-methylaniline is replaced by an isopropyl or a phenyl group, trisolvated monomers are formed instead of dimers. Interestingly, the solid-state structure of lithiated N-isobutylaniline in tetrahydrofuran is a trisolvated dimer while that of lithium N-neopentylanilide is a disolvated dimer.

  DOI：

  10.1021/jo402498z