| 38363-83-6

• CAS: 38363-83-6
• 化学式: Cl₂Cu*Li
• 分子量: 141.393
• InChiKey: VZFNVRRDXMBETQ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -1.62
• 重原子数：
  4.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  3,5-二叔丁基邻苯醌 、 铜 、 lithium chloride 以 四氢呋喃 为溶剂， 生成 、 Li2{Cu(3,5-di-tert-butyl-1,2-catecholate)2}
  参考文献：
  名称：

  Study of the dissolution of metallic copper in the presence of 3,5-di-tert-butyl-1,2-benzoquinone and lithium chloride in tetrahydrofuran

  摘要：

  DOI：

  10.1007/bf00959358
• 作为试剂：
  描述：

  1-bromo-1,1-dideuteriohexane 、 6-溴-1-己烯 在 Li⁽¹⁺⁾*CuCl₂^(1-)=LiCuCl₂ 、 magnesium 作用下， 生成 [7,7-2H2]-1-dodecene
  参考文献：
  名称：

  Deciphering the Cryptoregiochemistry of Oleate Δ¹² Desaturase:  A Kinetic Isotope Effect Study

  摘要：

  The intermolecular primary deuterium isotope effects on the individual C-H bond cleavage steps involved in linoleic acid biosynthesis were determined using a suitably transformed strain of Saccharomyces cerevisiae containing a functional oleate Delta(12) desaturase from Arabidopsis thaliana. Mass spectral analysis of the methyl 7-thialinoleate fraction obtained from competition experiments involving methyl 7-thiastearate, methyl [12,12-H-2(2)]-7-thiastearate and methyl [13,13-H-2(2)]-7-thiastearate showed that cleavage of the C-12-H bond is very sensitive to isotopic substitution (k(H)/k(D) = 7.3 +/- 0.4) while a negligible isotope effect (k(H)/k(D) = 1.05 +/- 0.04) was observed for the C-13-H bond breaking step. This result strongly suggests that the site of initial oxidation for Delta(12) desaturation is at C-12. The possible relationship between castor oleate 12-hydroxylase and microsomal Delta(12) oleate desaturases is discussed in the context of a common mechanistic paradigm. Our methodology may be also be useful in deciphering the cryptoregiochemistry of other desaturase systems.

  DOI：

  10.1021/ja971362i