| 1612767-62-0

• CAS: 1612767-62-0
• 化学式: C₂₁H₁₆Cl₂MnN₄O₃
• 分子量: 498.227
• InChiKey: FOLASXJBKIQVCN-UHFFFAOYSA-L

反应信息

• 作为产物：
  描述：

  manganese(II) chloride tetrahydrate 、 N-[2-([2,2':6',2"-terpyridin]-4'-yloxy)ethyl]maleimide 以 四氢呋喃 为溶剂， 反应 0.25h， 以57%的产率得到
  参考文献：
  名称：

  Manganese terpyridine artificial metalloenzymes for benzylic oxygenation and olefin epoxidation

  摘要：

  New catalysts for non-directed hydrocarbon functionalization have great potential in organic synthesis. We hypothesized that incorporating a Mn-terpyridine cofactor into a protein scaffold would lead to artificial metalloenzymes (ArMs) in which the selectivity of the Mn cofactor could be controlled by the protein scaffold. We designed and synthesized a maleimide-substituted Mn-terpyridine cofactor and demonstrated that this cofactor could be incorporated into two different scaffold proteins to generate the desired ArMs. The structure and reactivity of one of these ArMs was explored, and the broad oxygenation capability of the Mn-terpyridine catalyst was maintained, providing a robust platform for optimization of ArMs for selective hydrocarbon functionalization.

  DOI：

  10.1016/j.tet.2014.03.008