Ru₂(CO)₄(μ₂-η²-indomethacin(1-))₂(triphenylphosphine)₂ | 1415298-39-3

• 英文名称: Ru₂(CO)₄(μ₂-η²-indomethacin(1-))₂(triphenylphosphine)₂
• CAS: 1415298-39-3
• 化学式: C₇₈H₆₀Cl₂N₂O₁₂P₂Ru₂
• 分子量: 1552.33
• InChiKey: PPZQFSHKKUREQX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  Ru₂(CO)₄(μ₂-η²-indomethacin(1-))₂(tetrahydrofuran)₂ 、 三苯基膦 以 四氢呋喃 为溶剂， 反应 3.0h， 以83%的产率得到Ru₂(CO)₄(μ₂-η²-indomethacin(1-))₂(triphenylphosphine)₂
  参考文献：
  名称：

  Sawhorse-type diruthenium tetracarbonyl complexes containing biologically relevant acids

  摘要：

  The reaction between the biologically active acids probenecid (HO2CC12H18NO2S), indomethacin (HO2CC18H15ClNO2) and sulindac (HO2CC19H16FOS) with Ru-3(CO)(12), followed by addition of axial ligands (L), such as pyridine, triphenylphosphine, or 5-(4-pyridyl)-10,15,20-triphenylporphyrin, generates a series of stable diruthenium tetracarbonyl complexes of the formula Ru-2(CO)(4)(mu(2)-eta(2)-O2CC12H18NO2S)(2)L-2, Ru-2(CO)(4)(mu(2)-eta(2)-O2CC18H15ClNO2)(2)L-2 and Ru-2(CO)(4)(mu(2)-eta(2)-O2CC19H16FOS)(2)L-2, respectively. The molecular structure of 1a center dot C6H6 was solved by single-crystal X-ray structure analysis and a typical diruthenium tetracarbonyl backbone bridged by the carboxylato ligands and two axial triphenylphosphine ligands was revealed. The benzene molecule sits between two probenecid units, and is involved in pi-stacking interactions with the aromatic part of probenecid. Despite the presence of biologically relevant derivatives and carbonyl groups within the sawhorse-type dinuclear complexes, all systems show no cytotoxicity towards human cancer cells, presumably due to the high lipophilicity of these neutral complexes. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.09.034