2-(4-Hydroxyphenyl)sulfanyl-1-(2-methoxyphenyl)ethanone | 397849-19-3

• 英文名称: 2-(4-Hydroxyphenyl)sulfanyl-1-(2-methoxyphenyl)ethanone
• CAS: 397849-19-3
• 化学式: C₁₅H₁₄O₃S
• 分子量: 274.34
• InChiKey: LJUOUIPYWQZYBF-UHFFFAOYSA-N

物化性质

• 沸点：
  458.7±35.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-Hydroxyphenyl)sulfanyl-1-(2-methoxyphenyl)ethanone 生成 、
  参考文献：
  名称：

  Wang p -alkoxyphenylsulfoxide as a new linker and Pummerer cleavage strategy in solid-phase preparation of 1,2-diols

  摘要：

  para-Hydroxyphenyl-beta -ketosulfide was attached to a Wang resin and oxidised to the corresponding sulfoxide with a N-protonated oxaziridinium trifluoroacetate. Reduction of the beta -ketosulfoxides to the corresponding beta -hydroxysulfoxides with Dibal-H was shown to be as stereoselective as in solution. Finally it was shown that the Pummerer reaction could be carried out on solid-phase and was a very efficient way to obtain diols that validates the sulfoxide group as a versatile linker for solid-phase chemistry. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01557-x
• 作为产物：
  描述：

  邻甲氧基-2-溴苯乙酮 、 4-羟基苯硫酚 在 potassium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 2-(4-Hydroxyphenyl)sulfanyl-1-(2-methoxyphenyl)ethanone
  参考文献：
  名称：

  Wang p -alkoxyphenylsulfoxide as a new linker and Pummerer cleavage strategy in solid-phase preparation of 1,2-diols

  摘要：

  para-Hydroxyphenyl-beta -ketosulfide was attached to a Wang resin and oxidised to the corresponding sulfoxide with a N-protonated oxaziridinium trifluoroacetate. Reduction of the beta -ketosulfoxides to the corresponding beta -hydroxysulfoxides with Dibal-H was shown to be as stereoselective as in solution. Finally it was shown that the Pummerer reaction could be carried out on solid-phase and was a very efficient way to obtain diols that validates the sulfoxide group as a versatile linker for solid-phase chemistry. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01557-x