(PhC*C-CH(OH)-(i)Pr)Co2(CO)5(triphenylphosphine) | 118576-67-3

• 英文名称: (PhC*C-CH(OH)-(i)Pr)Co2(CO)5(triphenylphosphine)
• CAS: 118576-67-3
• 化学式: C₃₅H₂₉Co₂O₆P
• 分子量: 694.572
• InChiKey: LBVRJCVFXYRXFP-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  (PhC*C-CH(OH)-(i)Pr)Co2(CO)6 、 三苯基膦 在 番木鳖碱N-氧化物水合物 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (PhC*C-CH(OH)-(i)Pr)Co2(CO)5(triphenylphosphine)
  参考文献：
  名称：

  Some studies involving the use of chiral amine oxides for the enantioselective preparation of (propargyl alcohol)Co2(CO)5(PR3) complexes

  摘要：

  The enantioselective preparation of (propargyl alcohol) dicobalt pentacarbonylphosphine complexes (2) via kinetic resolution with an optically active amine oxide was examined. Variations in temperature, solvent, phosphine, amine oxide, and substrate were studied. Diastereoselectivity showed marked improvement over thermal methods, while enantioselectivity was modest. The typical e.e. for product 2a was 20% at 30-40% conversion when the reaction was carried out at -58 degrees C in a 1:1 mixture of tetrahydrofuran/dichloromethane with brucine N-oxide as the promoter. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(99)00077-7