N-(4-ferrocenylphenyl-N’-(3,4-dichlorophenyl))-N”-benzoylguanidine | 1485525-22-1

• 英文名称: N-(4-ferrocenylphenyl-N’-(3,4-dichlorophenyl))-N”-benzoylguanidine
• CAS: 1485525-22-1
• 化学式: C₃₀H₂₃Cl₂FeN₃O
• 分子量: 568.285
• InChiKey: RZSQLSZMZAICEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  4-ferrocenylaniline 、 N-benzoyl-N’-(3,4-dichlorophenyl)thiourea 在 三乙胺 、 mercury dichloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以73%的产率得到N-(4-ferrocenylphenyl-N’-(3,4-dichlorophenyl))-N”-benzoylguanidine
  参考文献：
  名称：

  Preliminary investigation of anticancer activity by determining the DNA binding and antioxidant potency of new ferrocene incorporated N,N′,N″-trisubstituted phenylguanidines

  摘要：

  Six new bioactive ferrocene based phenylguanidines were successively synthesized and characterized by means of various analytical techniques like elemental analysis, FT-IR, multinuclear (H-1 and C-13) NMR, UV-Vis spectroscopy and cyclic voltammetry. The interaction of compounds with DNA was investigated by spectroscopic and cyclic voltammetric measurements. The interaction was found to be the electrostatic and the binding constants values were impressively larger. Compounds f-1, f-2, f-3 have slight larger binding constant values ranging from 0.8 x 10(5) to 2.4 x 10(5) as compared to g-1, g-2 and g-3 ranging from 7.6 x 10(4) to 1.1 x 10(5) which is most probably due to the presence of ferrocene at para position where the delocalization of electrons is maximum. Antioxidant activity was determined by UV-Vis spectrophotometer by using DPPH as a free radical. All the compounds exhibit good antioxidant activity and the results so obtained support the structure activity relationship. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2013.08.033