7-chloro-4-(4,7-diferrocenylmethyl-1,4,7-triazacyclononan-1-yl)quinoline | 830355-10-7

• 英文名称: 7-chloro-4-(4,7-diferrocenylmethyl-1,4,7-triazacyclononan-1-yl)quinoline
• CAS: 830355-10-7
• 化学式: C₃₇H₃₉ClFe₂N₄
• 分子量: 686.89
• InChiKey: OKQSFQQNTFUPBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• sp3杂化的碳原子比例：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  4,7-二氯喹啉 、 N,N,N-(ferrocenylmethyl)trimethylammonium iodide 、 1,4,7-triazacyclononane trihydrochloride 在 potassium carbonate 作用下， 以 further solvent(s) 为溶剂， 以40%的产率得到7-chloro-4-[4-(7-chloro-4-quinolyl)-7-ferrocenylmethyl-1,4,7-triazacyclononan-1-yl]quinoline
  参考文献：
  名称：

  Easily synthesized antimalarial ferrocene triazacyclononane quinoline conjugates

  摘要：

  Starting from triazacyclononane, easily accessible ferrocenic quinoline derivatives were synthesized. Their antiplasmodial properties were investigated against chloroquine sensitive (HB3) and chloroquine-resistant (Dd2) Plasmodium falciparum. One of them, 7-chloro-4-[4-(7-chloro-4-quinolyl)-7-ferrocenylmethyl-1,4,7-triazacyclononan-1-yl]quinoline (4) showed potent antimalarial activity in vitro against the chloroquine-resistant strain Dd2 and therefore revealed to be the most promising lead from the present work for new organometallic antimalarial agents. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2004.04.036