(R)-2-methyl-1-((R)-2-methyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-propyl)-pyrrolidine | 1382182-76-4

• 英文名称: (R)-2-methyl-1-((R)-2-methyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-propyl)-pyrrolidine
• CAS: 1382182-76-4
• 化学式: C₂₁H₃₄BNO₃
• 分子量: 359.317
• InChiKey: KGKYWJGLZJRLGO-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.49
• 重原子数：
  26.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  30.93
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (R)-2-methyl-1-((R)-2-methyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-propyl)-pyrrolidine 、 2-hydroxymethyl-5-iodo-2H-pyridazin-3-one 在 四(三苯基膦)钯 、 potassium carbonate 、 sodium cyanoborohydride 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 反应 0.08h， 以39%的产率得到5-(4-[(R)-2-methyl-3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl)-2H-pyridazin-3-one
  参考文献：
  名称：

  Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists

  摘要：

  A novel series of 4-pyridazin-3-one and 5-pyridazin-3-one analogues were designed and synthesized as H3R antagonists. Structure-activity relationship revealed the 5-pyridazin-3-ones 8a and S-methyl 8b had excellent human and rat H3R affinities, and acceptable pharmacokinetic properties. In vivo evaluation of 8a showed potent activity in the rat dipsogenia model and robust wake-promoting activity in the rat EEG/EMG model. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.04.028
• 作为产物：
  描述：

  (S)-2-methyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl methanesulfonate 、 (R)-2-methylpyrrolidine hydrochloride 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 22.0h， 以48%的产率得到(R)-2-methyl-1-((R)-2-methyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-propyl)-pyrrolidine
  参考文献：
  名称：

  Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists

  摘要：

  A novel series of 4-pyridazin-3-one and 5-pyridazin-3-one analogues were designed and synthesized as H3R antagonists. Structure-activity relationship revealed the 5-pyridazin-3-ones 8a and S-methyl 8b had excellent human and rat H3R affinities, and acceptable pharmacokinetic properties. In vivo evaluation of 8a showed potent activity in the rat dipsogenia model and robust wake-promoting activity in the rat EEG/EMG model. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.04.028