| 1607836-85-0

• CAS: 1607836-85-0
• 化学式: C₂₁H₁₁Cl₃F₄IrN₃
• 分子量: 679.911
• InChiKey: HHQLFJFRTUQRDI-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  硝酸铵 、 、 4'-(2,3,5,6-tetrafluorophenyl)-2,2':6',2''-terpyridine 以 乙二醇 、 水 为溶剂， 反应 2.0h， 以0.11 g的产率得到
  参考文献：
  名称：

  Stabilization of Cucurbituril/Guest Assemblies via Long-Range Coulombic and CH···O Interactions

  摘要：

  Cucurbit[n]urils (CB[n], n = 6-8) interact strongly with metal-bound 4'-substituted terpyridine ligands (M = Fe(II) and Ir(III)) via CH center dot center dot center dot O hydrogen bonding, despite significant separation between the positive metallic cation and the carbonylated rim of CB[n], and the location of the latter in the second coordination sphere of the metal ion. While water has been shown to mediate interactions between cations and CB[n]s in some assemblies, mediation by organic ligands is unprecedented. The recognition process is driven by the contrasted combination of extremely favorable binding enthalpies (up to 20.2 kcal/mol) and very unfavorable entropic components (as low as -10.2 kcal/mol). Dynamic oligomers were prepared in the presence of CB[8], which acts as a "soft", noncovalent linker between metal/terpyridine complexes, and interconnects two 4'-substituents inside its cavity. Social self-sorting between CB[8] and metal/terpyridine complexes bearing 4'-(2-naphthyl) and 4'-(2,3,5,6-tetrafluorophenyl) substituents was also observed, and could afford well-organized oligomers with alternating Fe(II) and Ir(III) cations.

  DOI：

  10.1021/ja4092165
• 作为产物：
  描述：

  2-乙酰基吡啶 在 sodium hydroxide 作用下， 以 乙二醇 为溶剂， 反应 46.0h， 生成
  参考文献：
  名称：

  Stabilization of Cucurbituril/Guest Assemblies via Long-Range Coulombic and CH···O Interactions

  摘要：

  Cucurbit[n]urils (CB[n], n = 6-8) interact strongly with metal-bound 4'-substituted terpyridine ligands (M = Fe(II) and Ir(III)) via CH center dot center dot center dot O hydrogen bonding, despite significant separation between the positive metallic cation and the carbonylated rim of CB[n], and the location of the latter in the second coordination sphere of the metal ion. While water has been shown to mediate interactions between cations and CB[n]s in some assemblies, mediation by organic ligands is unprecedented. The recognition process is driven by the contrasted combination of extremely favorable binding enthalpies (up to 20.2 kcal/mol) and very unfavorable entropic components (as low as -10.2 kcal/mol). Dynamic oligomers were prepared in the presence of CB[8], which acts as a "soft", noncovalent linker between metal/terpyridine complexes, and interconnects two 4'-substituents inside its cavity. Social self-sorting between CB[8] and metal/terpyridine complexes bearing 4'-(2-naphthyl) and 4'-(2,3,5,6-tetrafluorophenyl) substituents was also observed, and could afford well-organized oligomers with alternating Fe(II) and Ir(III) cations.

  DOI：

  10.1021/ja4092165

文献信息

• Tracking mitochondrial dynamics during apoptosis with phosphorescent fluorinated iridium(<scp>iii</scp>) complexes
  作者：Chen Zhang、Kangqiang Qiu、Chaofeng Liu、Huaiyi Huang、Thomas W. Rees、Liangnian Ji、Qianling Zhang、Hui Chao

  DOI：10.1039/c8dt02918k

  日期：——

  Mitochondria are the control centers of apoptosis. To study mitochondrial dynamics during apoptosis, four phosphorescent fluorinated iridium(III) complexes (Ir1–Ir4) were designed and synthesized. The complexes' emission maxima, phosphorescent quantum yields, and phosphorescent lifetimes are tuned by the degree of fluorination of the ligand. The complexes exhibit excellent photostability and low (photo)cytotoxicity

  线粒体是细胞凋亡的控制中心。为了研究细胞凋亡过程中的线粒体动力学，设计并合成了四种磷光氟化铱（III）配合物（Ir1-Ir4）。配合物的氟化程度可调节配合物的发射最大值，磷光量子产率和磷光寿命。该复合物在HeLa细胞中显示出极好的光稳定性和低（光）细胞毒性。由于复合物是阳离子和亲脂性的，因此它们位于线粒体中，并通过能量非依赖性途径进入细胞。与市售的线粒体跟踪仪（例如MTR）相比，Ir1-Ir4甚至在固定细胞中也表现出对线粒体的高度特异性。由于这些突出的特性，复合物已成功用于跟踪细胞凋亡过程中的线粒体动力学。