hexacarbonyl[1-{2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt | 1412443-39-0

• 英文名称: hexacarbonyl[1-{2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt
• CAS: 1412443-39-0
• 化学式: C₂₆H₂₇Co₂NO₁₀
• 分子量: 631.487
• InChiKey: HGHJWLRQFBJRDL-CVMAAMKCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  hexacarbonyl[1-{2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt 在 硝酸铈(3+)铵 、 三氟化硼乙醚 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 0.58h， 生成 3-(1-fluoro-1-methylethyl)-4-(N-Boc-methylaminoethynyl)chromane
  参考文献：
  名称：

  A highly diastereoselective series of Nicholas cyclisation reactions of N-Boc-protected propargylamines

  摘要：

  The reaction of N-Boc-protected propargylamine with salicylaldehyde derivatives and their subsequent Nicholas cyclisation reaction to provide a range of novel benzopyrans is reported. The cyclisation reactions proceeded with excellent levels of diastereoselectivity to afford compounds with cis-relative stereochemistry. As far as we are able to ascertain these are the first reported examples of Nicholas cyclisation reactions of propargyl alcohols that bear a terminal alkynyl N-protected amino motif. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.087
• 作为产物：
  描述：

  2-(3-methyl-2-butenyloxy)benzaldehyde 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正庚烷 、 二氯甲烷 为溶剂， 反应 1.67h， 生成 hexacarbonyl[1-{2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt
  参考文献：
  名称：

  A highly diastereoselective series of Nicholas cyclisation reactions of N-Boc-protected propargylamines

  摘要：

  The reaction of N-Boc-protected propargylamine with salicylaldehyde derivatives and their subsequent Nicholas cyclisation reaction to provide a range of novel benzopyrans is reported. The cyclisation reactions proceeded with excellent levels of diastereoselectivity to afford compounds with cis-relative stereochemistry. As far as we are able to ascertain these are the first reported examples of Nicholas cyclisation reactions of propargyl alcohols that bear a terminal alkynyl N-protected amino motif. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.087