dichlorobis[di-(2-furyl)methylcyclopentadienyl]titanium(IV) | 910098-14-5

• 英文名称: dichlorobis[di-(2-furyl)methylcyclopentadienyl]titanium(IV)
• CAS: 910098-14-5
• 化学式: C₂₈H₂₂Cl₂O₄Ti
• 分子量: 541.266
• InChiKey: XENQPNIZHZXMSE-UHFFFAOYSA-L

计算性质

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反应信息

• 作为产物：
  描述：

  呋喃 、 2-(环戊-2,4-二烯-1-亚基甲基)呋喃 、 四氯化钛 在 n-butyl lithium 作用下， 以 四氢呋喃 为溶剂， 以55%的产率得到dichlorobis[di-(2-furyl)methylcyclopentadienyl]titanium(IV)
  参考文献：
  名称：

  Diheteroarylmethyl substituted titanocenes: A novel class of possible anti-cancer drugs

  摘要：

  From the reaction of tert-butyl lithium or n-butyl lithium with N-methylpyrrole (1a), furan (1b) or 2-bromo-thiophen (1c), 2-N-methylpyrrolyl lithium (2a), 2-furyl lithium (2b) or 2-thiophenyl lithium (2c), respectively, was obtained. When reacted with 6-(2-N-methylpyrrolyl) fulvene (3a), 6-(2-furyl) fulvene (3b) or 6-(2-thiophenyl) fulvene (3c), the corresponding lithiated intermediates were formed (4a-c). Titanocenes (5a-c) were obtained through transmetallation with titanium tetrachloride. When these titanocenes were tested against pig kidney epithelial (LLC-PK) cells, inhibitory concentrations (IC50) of 32 mu M, 140 mu M, and 240 mu M, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, compared to their ansa-analogues. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2006.05.021