10-(4-((4-((7-(2-(dimethylamino)ethoxy)benzofuro[3,2-b]quinolin-11-yl)amino)butyl)amino)-4-oxobutyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-dipyrrolo[1,2-c:2',1'-f] [1,3,2]diazaborinin-4-ium-5-uide | 1588424-88-7

• 英文名称: 10-(4-((4-((7-(2-(dimethylamino)ethoxy)benzofuro[3,2-b]quinolin-11-yl)amino)butyl)amino)-4-oxobutyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-dipyrrolo[1,2-c:2',1'-f] [1,3,2]diazaborinin-4-ium-5-uide
• CAS: 1588424-88-7
• 化学式: C₄₀H₄₇BF₂N₆O₃
• 分子量: 708.659
• InChiKey: DOKOJOXLVSQDFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  在 偶氮二甲酸二异丙酯 、 三溴化硼 、 三苯基膦 作用下， 以 二氯甲烷 、 氯仿 、 N,N-二甲基甲酰胺 、 苯酚 为溶剂， 反应 156.0h， 生成 10-(4-((4-((7-(2-(dimethylamino)ethoxy)benzofuro[3,2-b]quinolin-11-yl)amino)butyl)amino)-4-oxobutyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-dipyrrolo[1,2-c:2',1'-f] [1,3,2]diazaborinin-4-ium-5-uide
  参考文献：
  名称：

  Synthesis and evaluation of new BODIPY-benzofuroquinoline conjugates for sensitive and selective DNA detection

  摘要：

  The sensitive and selective detection of nucleic acids is important for basic research and many applied fields. Herein, a series of new BODIPY-benzofuroquinoline conjugates were designed, synthesized and evaluated as DNA intercalating dyes. All compounds were characterized by using H-1, C-13 NMR, IR, UV-Vis and fluorescence spectroscopy, and DNA binding properties of these conjugates to calf thymus DNA were studied by using fluorescence titration, UV titration, isothermal titration calorimetry and CD analysis. Significant enhancement of the fluorescent quantum yield was observed for all the conjugates in the presence of calf thymus DNA, and one compound showed excellent sensitivity and selectivity offering its potential application as a DNA specific fluorescent probe. Our results showed that these conjugates could intercalate into calf thymus DNA with high binding affinities. The properties of these dyes as fluorescent probes for living cells imaging were also investigated. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2014.03.027