| 947335-03-7

• CAS: 947335-03-7
• 化学式: C₁₆H₁₆Cl₂NTi*Cl
• 分子量: 376.549
• InChiKey: RJVCJXYZHHGBFV-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  盐酸 、 (2-picolyl)cyclopentadienyllithium 、 三氯一茂钛 以 四氢呋喃 为溶剂， 以74%的产率得到
  参考文献：
  名称：

  A new series of titanocene dichloride derivatives bearing cyclic alkylammonium groups: Assessment of their cytotoxic properties

  摘要：

  Ten new water soluble titanocene dichloride derivatives have been synthesized and characterized and their cytotoxicities against the human lung cancer cell line A549 have been assessed. The potencies of the compounds vary greatly, but dicationic 3-picolylium and 4-picolylium compounds exhibit IC50 values that are unusually low for this class of compounds. In view of their potency against A549 cells, three of the new complexes were tested further on additional human cell lines including the small cell lung cancer cell line H69, the widely used cervical carcinoma cell line HeLa, the ovarian carcinoma cell line A2780 and its cisplatin resistant derivative A2780/CP. All three compounds exhibited potencies in all cell lines comparable to or better than those observed with the A549 cells, while one complex is actually more potent than cisplatin for HeLa cells. (c) 2007 Published by Elsevier B.V.

  DOI：

  10.1016/j.jorganchem.2007.04.024