| 1610505-93-5

• CAS: 1610505-93-5
• 化学式: C₃₆H₂₉BF₂N₄O₂
• 分子量: 598.46
• InChiKey: ADSAJIXWJWOBDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  tetra[μ-acetato-bis(methanol)]dirhodium 、 以 丙酮 为溶剂， 反应 24.0h， 以25%的产率得到
  参考文献：
  名称：

  Confocal Fluorescence Microscopy Studies of a Fluorophore-Labeled Dirhodium Compound: Visualizing Metal–Metal Bonded Molecules in Lung Cancer (A549) Cells

  摘要：

  The new dirhodium compound [Rh-2-mu-O2CCH3)(2)(eta(1)-O2CCH3)(phenbodipy)(H2O)(3)]-[O2CCH3] (1), which incorporates a bodipy fluorescent tag, was prepared and studied by confocal fluorescence microscopy in human lung adenocarcinoma (A549) cells. It was determined that 1 localizes mainly in lysosomes and mitochondria with no apparent nuclear localization in the 1-100 mu M range. These results support the conclusion that cellular organelles rather than the nucleus can be targeted by modification of the ligands bound to the Rh-2(4+) core. This is the first study of a fluorophore-labeled metal-metal bonded compound, work that opens up new venues for the study of intracellular distribution of dinuclear transition metal anticancer complexes.

  DOI：

  10.1021/ja503774m
• 作为产物：
  描述：

  1,10-菲罗啉 在 4-二甲氨基吡啶 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 发烟硫酸 、 溴 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 二异丙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 79.0h， 生成
  参考文献：
  名称：

  Confocal Fluorescence Microscopy Studies of a Fluorophore-Labeled Dirhodium Compound: Visualizing Metal–Metal Bonded Molecules in Lung Cancer (A549) Cells

  摘要：

  The new dirhodium compound [Rh-2-mu-O2CCH3)(2)(eta(1)-O2CCH3)(phenbodipy)(H2O)(3)]-[O2CCH3] (1), which incorporates a bodipy fluorescent tag, was prepared and studied by confocal fluorescence microscopy in human lung adenocarcinoma (A549) cells. It was determined that 1 localizes mainly in lysosomes and mitochondria with no apparent nuclear localization in the 1-100 mu M range. These results support the conclusion that cellular organelles rather than the nucleus can be targeted by modification of the ligands bound to the Rh-2(4+) core. This is the first study of a fluorophore-labeled metal-metal bonded compound, work that opens up new venues for the study of intracellular distribution of dinuclear transition metal anticancer complexes.

  DOI：

  10.1021/ja503774m