ferrocene acetic acid N-hydroxysuccinimide ether | 123951-06-4

• 英文名称: ferrocene acetic acid N-hydroxysuccinimide ether
• 英文别名: acetylferrocene-N-hydroxy-succinimido ester
• CAS: 123951-06-4
• 化学式: C₁₆H₁₅FeNO₄
• 分子量: 341.146
• InChiKey: ZYMIFBVKIREWOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  ferrocene acetic acid N-hydroxysuccinimide ether 、 N^α-(tert-butyloxycarbonyl)-(R)-lysine tert-butyl ester 在 sodium carbonate 作用下， 以 乙腈 为溶剂， 以73%的产率得到
  参考文献：
  名称：

  非天然氨基酸 NN-(二茂铁-1-乙酰基)-l-赖氨酸的合成：一种新型有机金属核酸酶。

  摘要：

  The synthesis of a new unnatural amino acid, N-alpha-N-epsilon-(ferrocene-1-acetyl)-L-lysine, was achieved by coupling a ferroceneacetic acid molecule onto the side chain amine of a lysine. The structure of the compound provides options for incorporation of the molecule into peptides or large proteins. In addition, N-alpha-N-epsilon-(ferrocene-1-acetyl)-L-lysine exhibits nuclease activity. It is expected that incorporation of this ferrocenyl amino acid into any nucleic acid-binding protein will endow the protein with nuclease capability. (C) 2008 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2008.06.012
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 二茂铁基乙酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 ferrocene acetic acid N-hydroxysuccinimide ether
  参考文献：
  名称：

  非天然氨基酸 NN-(二茂铁-1-乙酰基)-l-赖氨酸的合成：一种新型有机金属核酸酶。

  摘要：

  The synthesis of a new unnatural amino acid, N-alpha-N-epsilon-(ferrocene-1-acetyl)-L-lysine, was achieved by coupling a ferroceneacetic acid molecule onto the side chain amine of a lysine. The structure of the compound provides options for incorporation of the molecule into peptides or large proteins. In addition, N-alpha-N-epsilon-(ferrocene-1-acetyl)-L-lysine exhibits nuclease activity. It is expected that incorporation of this ferrocenyl amino acid into any nucleic acid-binding protein will endow the protein with nuclease capability. (C) 2008 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2008.06.012