1-(N-tert-Boc-phenylalanyl)amidomethyl-1,2-dicarba-closo-dodecaborane(12) | 224790-11-8

• 英文名称: 1-(N-tert-Boc-phenylalanyl)amidomethyl-1,2-dicarba-closo-dodecaborane(12)
• CAS: 224790-11-8
• 化学式: C₁₇H₃₂B₁₀N₂O₃
• 分子量: 420.563
• InChiKey: PZSSKOSTXOUVME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  N-甲基-N-叔丁氧羰基-D-苯丙氨酸 、 1-NH2CH2-1,2-closo-C2B10H11 、 N,N'-羰基二咪唑 在 吡啶 作用下， 以 四氢呋喃 、 吡啶 为溶剂， 以88%的产率得到1-(N-tert-Boc-phenylalanyl)amidomethyl-1,2-dicarba-closo-dodecaborane(12)
  参考文献：
  名称：

  Coupling of Amino Carboranes to Carboxylic Acid Containing Substrates

  摘要：

  The reactivity of the known amino carboranes 1-H2NCH2-1,2-C2B10H11 and 7-H3N-7-CB10H12 With carboxylic acid containing substrates was investigated. The reactions studied using the coupling reagent, 1,1'-carbonyldiimidazole, resulted in the preparation of a series of amides in moderate to high yield. The relative importance of this type of research resides in the fact that it allows the introduction of amino acids in close contact with the carborane cage. These compounds can constitute a new generation of substrates useful in boron neutron capture therapy. Our emphasis lies in the development of suitable synthetic schemes allowing the preparation of this type of compound. Experimental details and analytical data supporting the formulation of the prepared compounds are reported.

  DOI：

  10.1021/ic981223h