(R)-(3,4-dimethoxyphenyl)(2-methoxyphenyl)phenylphosphane-borane (1/1) | 264871-36-5

• 英文名称: (R)-(3,4-dimethoxyphenyl)(2-methoxyphenyl)phenylphosphane-borane (1/1)
• CAS: 264871-36-5；264124-31-4
• 化学式: C₂₁H₂₄BO₃P
• 分子量: 366.205
• InChiKey: SMOIDNVGVCUKDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  4-溴黎芦醚 、 methyl (R)-(-)-(2-methoxyphenyl)phenylphosphinite borane complex 在 n-BuLi 作用下， 以 四氢呋喃 为溶剂， 以80%的产率得到(R)-(3,4-dimethoxyphenyl)(2-methoxyphenyl)phenylphosphane-borane (1/1)
  参考文献：
  名称：

  Formation of Diastereoisomerically Pure Oxazaphospholes and Their Reaction to Chiral Phosphane-Borane Adducts

  摘要：

  Starting with achiral phosphines and (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol ((+)-pseudoephedrine) or (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol ((-)-ephedrine), as chiral auxiliaries, diastereoisomerically pure oxazaphospholes wore prepared (Scheme 1). The configuration at the P-atom is controlled by the configuration at the Ph-substituted C(1) of (+)-pseudoephedrine or (-)-ephedrine, respectively. This was confirmed by X-ray crystal-structure analyses of two intermediate compounds in the synthesis route to the chiral triarylborane-phosphane adducts.

  DOI：

  10.1002/(sici)1522-2675(20000216)83:2<311::aid-hlca311>3.0.co;2-i