[Ru(II)(η6-p-isopropyltoluene)(2,3-pyridinedicarboxylato)Cl] | 1221293-23-7

• 英文名称: [Ru(II)(η6-p-isopropyltoluene)(2,3-pyridinedicarboxylato)Cl]
• 英文别名: [Ru(II)(η6-p-cym)(pydc)Cl]
• CAS: 1221293-23-7
• 化学式: C₁₇H₁₈ClNO₄Ru
• 分子量: 436.857
• InChiKey: LXHQNLUNYDBLID-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  [Ru(II)(η6-p-isopropyltoluene)(2,3-pyridinedicarboxylato)Cl] 、 L-组氨酸 在 NaCl 、 NaClO₄ or Hepes buffer 作用下， 以 水 为溶剂， 生成 [Ru(II)(η6-p-isopropyltoluene)(2,3-pyridinedicarboxylato)(L-histidine)](1+)
  参考文献：
  名称：

  Kinetics and mechanism of the reactions of Ru(II)–arene complex with some biologically relevant ligands

  摘要：

  The reactions of ruthenium(II)-arene complex [Ru-II(eta(6)-p-cym)(pydc)Cl] (where p-cym = p-isopropyl toluene, pydc = 2,3-pyridinedicarboxylato) with biologically nitrogen-donor nucleophiles, such as guanosine-5'-monophosphate (5'-GMP), guanosine (Guo) and L-histidine (L-His) were studied by UV-Vis spectrophotometry and H-1 NMR spectroscopy. The reactions were studied at pH 2.5 and at 7.2. All reactions were followed under pseudo-first order conditions with large excess of the nucleophiles. The selected nucleophiles have a high affinity for Ru(II)-arene complex. The reactivity of the used ligands follow the same order at both pH values: Guo > 5'-GMP > L-His, while the reactions at pH 7.2 are always faster. The negative entropies of activation (Delta S-not equal) support an associative mode of activation. However, the rate constants obtained by H-1 NMR at 295 K in D2O follow the same order of the ligand reactivity. The hydrolysis of the [Ru-II(eta(6)-p-cym)(pydc)Cl] complex was very fast and completed by the time the first spectrum was measured. Addition of excess of NaCl to equilibrium solutions reversed the hydrolysis. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.06.019