((1S,2R,4R,5R)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-methyl-6-oxa-bicyclo[3.1.0]hex-2-yl)methanol | 943222-43-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: ((1S,2R,4R,5R)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-methyl-6-oxa-bicyclo[3.1.0]hex-2-yl)methanol
• CAS: 943222-43-3
• 化学式: C₁₂H₁₄ClN₅O₂
• 分子量: 295.728
• InChiKey: GLFZNEJBAYNJDX-NZKKVVHASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.77
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  102.38
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  ((1S,2R,4R,5R)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-methyl-6-oxa-bicyclo[3.1.0]hex-2-yl)methanol 、 环丙胺 以 四氢呋喃 为溶剂， 反应 2.0h， 以83%的产率得到((1S,2R,4R,5R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-1-methyl-6-oxa-bicyclo[3.1.0]hex-2-yl)methanol
  参考文献：
  名称：

  Chemoenzymatic synthesis of novel adenosine carbanucleoside analogues containing a locked 3′-methyl-2′,3′-β-oxirane-fused system

  摘要：

  Starting from a readily available enantiopure building block, a straightforward enantioselective approach to 3 '-methyl-2 ',3 '- beta-oxirane-fused carbanucleosides bearing adenosine analogues is detailed. The key steps in the syntheses involved a lipase-catalyzed regioseleclive monoacylation of a diol to obtain the key intermediate and direct coupling of this key intermediate with diversely substituted purine nucleobases under Mitsunobu reaction conditions providing only the N-9 target molecules. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.122
• 作为产物：
  描述：

  (1S,2S,4S,5R)-4-acetoxy-1-methyl-6-oxa-bicyclo[3.1.0]hexane-2-carboxylic acid ethyl ester 在 Rhysomucor meihei lipase lithium aluminium tetrahydride 、 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 28.0h， 生成 ((1S,2R,4R,5R)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-methyl-6-oxa-bicyclo[3.1.0]hex-2-yl)methanol
  参考文献：
  名称：

  Chemoenzymatic synthesis of novel adenosine carbanucleoside analogues containing a locked 3′-methyl-2′,3′-β-oxirane-fused system

  摘要：

  Starting from a readily available enantiopure building block, a straightforward enantioselective approach to 3 '-methyl-2 ',3 '- beta-oxirane-fused carbanucleosides bearing adenosine analogues is detailed. The key steps in the syntheses involved a lipase-catalyzed regioseleclive monoacylation of a diol to obtain the key intermediate and direct coupling of this key intermediate with diversely substituted purine nucleobases under Mitsunobu reaction conditions providing only the N-9 target molecules. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.122